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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/158701
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dc.contributor.authorBosch Hereu, Lluís-
dc.contributor.authorDelelis, Olivier-
dc.contributor.authorSubra, Frédéric-
dc.contributor.authorDeprez, Eric-
dc.contributor.authorWitvrow, Myriam-
dc.contributor.authorVilarrasa i Llorens, Jaume-
dc.date.accessioned2020-05-05T09:21:37Z-
dc.date.available2020-05-05T09:21:37Z-
dc.date.issued2012-03-01-
dc.identifier.issn0040-4039-
dc.identifier.urihttp://hdl.handle.net/2445/158701-
dc.description.abstractN3 of thymidine and of 3′-azido-3′-deoxythymidine (AZT) has been linked to a tetrazole ring by condensation of nucleoside-derived 2-oxonitriles with the lithium salt of 5-acetyl-1-(4-fluorobenzyl)tetrazole (obtained by a 'click' reaction). 4-Acetyl-1,2,3-triazole, also prepared by a Cu-catalysed cycloaddition, has been similarly linked. A route for the conjugation of NRTIs with pharmacophoric elements of integrase inhibitors (INIs) has thus been disclosed.-
dc.format.extent5 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier Ltd-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1016/j.tetlet.2011.11.079-
dc.relation.ispartofTetrahedron Letters, 2012, vol. 53, num. 3, p. 514-518-
dc.relation.urihttps://doi.org/10.1016/j.tetlet.2011.11.079-
dc.rights(c) Elsevier Ltd, 2012-
dc.sourceArticles publicats en revistes (Química Inorgànica i Orgànica)-
dc.subject.classificationVIH (Virus)-
dc.subject.classificationInhibidors de la integrasa-
dc.subject.classificationIntegrase inhibitors-
dc.subject.otherHIV (Viruses)-
dc.titleThymidine- and AZT-linked 5-(1,3-dioxoalkyl)tetrazoles and 4-(1,3-dioxoalkyl)-1,2,3-triazoles-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec611183-
dc.date.updated2020-05-05T09:21:37Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
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