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dc.contributor.authorLlop Talaverón, Josep Manuel-
dc.contributor.authorLeiva Badosa, Elisabet-
dc.contributor.authorNovak, Ana-
dc.contributor.authorRigo Bonnin, Raúl-
dc.contributor.authorTicó Grau, Josep R.-
dc.contributor.authorSuñé i Negre, Josep M. (Josep Maria)-
dc.contributor.authorSuárez Lledó, Ana-
dc.contributor.authorLozano Andreu, Toni-
dc.contributor.authorBadía Tahull, Maria-
dc.description.abstractVegetable lipid emulsions (LE) contain non-declared phytosterols (PS). We aimed to determine PS content depending on the brand and LE batch; and in adult hospitalized patients treated with parenteral nutrition (PN), to establish the association between plasma and administered PS. I. LE study: Totals and fractions of PS in 3-4 non-consecutive batches from 6 LE were analysed. II. Patient study: randomized, double-blind study of patients with at least 7 previous days of PN with 0.8 g/kg/day of an olive/soybean LE, were randomized (Day 0) 1:1 to olive/soybean (O/S) or 100% fish oil (FO) at a dose of 0.4 g/kg/day for 7 days (Day 7). Plasma PS, its fractions, total cholesterol on Days 0 and 7, their clearance, and their association with PS administered by LE were studied. In part I. LE study: differences were found in the total PS, their fractions and cholesterol among different LE brands and batches. Exclusive soybean LE had the highest content of PS (422.36 ± 130.46 μg/mL). II. Patient study: 19 patients were included. In the O/S group, PS levels were maintained (1.11±6.98 μg/mL) from Day 0 to 7, while in the FO group, significant decreases were seen in total PS (-6.21±4.73 μg/mL) and their fractions, except for campesterol and stigmasterol. Plasma PS on Day 7 were significantly associated with PS administered (R2=0.443). PS content in different LE brands had great variability. PS administered during PN resulted in accumulation and could be prevented with the exclusive administration of FO
dc.format.extent26 p.-
dc.publisherCambridge University Press (CUP)ca
dc.relation.isformatofVersió postprint del document publicat a:
dc.relation.ispartofBritish Journal of Nutrition, 2020, vol. 123, num. 12, p. 1365-1372-
dc.rights(c) Llop Talaveron et al., 2020-
dc.sourceArticles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)-
dc.subject.classificationLípids de la sang-
dc.subject.otherBlood lipids-
dc.titlePhytosterolemia associated with parenteral nutrition administration in adult patientsca
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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