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http://hdl.handle.net/2445/158715
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DC Field | Value | Language |
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dc.contributor.author | Llop Talaverón, Josep Manuel | - |
dc.contributor.author | Leiva Badosa, Elisabet | - |
dc.contributor.author | Novak, Ana | - |
dc.contributor.author | Rigo Bonnin, Raúl | - |
dc.contributor.author | Ticó Grau, Josep R. | - |
dc.contributor.author | Suñé i Negre, Josep M. (Josep Maria) | - |
dc.contributor.author | Suárez Lledó, Ana | - |
dc.contributor.author | Lozano Andreu, Toni | - |
dc.contributor.author | Badía Tahull, Maria | - |
dc.date.accessioned | 2020-05-05T17:28:50Z | - |
dc.date.available | 2020-05-05T17:28:50Z | - |
dc.date.issued | 2020-02-20 | - |
dc.identifier.uri | http://hdl.handle.net/2445/158715 | - |
dc.description.abstract | Vegetable lipid emulsions (LE) contain non-declared phytosterols (PS). We aimed to determine PS content depending on the brand and LE batch; and in adult hospitalized patients treated with parenteral nutrition (PN), to establish the association between plasma and administered PS. I. LE study: Totals and fractions of PS in 3-4 non-consecutive batches from 6 LE were analysed. II. Patient study: randomized, double-blind study of patients with at least 7 previous days of PN with 0.8 g/kg/day of an olive/soybean LE, were randomized (Day 0) 1:1 to olive/soybean (O/S) or 100% fish oil (FO) at a dose of 0.4 g/kg/day for 7 days (Day 7). Plasma PS, its fractions, total cholesterol on Days 0 and 7, their clearance, and their association with PS administered by LE were studied. In part I. LE study: differences were found in the total PS, their fractions and cholesterol among different LE brands and batches. Exclusive soybean LE had the highest content of PS (422.36 ± 130.46 μg/mL). II. Patient study: 19 patients were included. In the O/S group, PS levels were maintained (1.11±6.98 μg/mL) from Day 0 to 7, while in the FO group, significant decreases were seen in total PS (-6.21±4.73 μg/mL) and their fractions, except for campesterol and stigmasterol. Plasma PS on Day 7 were significantly associated with PS administered (R2=0.443). PS content in different LE brands had great variability. PS administered during PN resulted in accumulation and could be prevented with the exclusive administration of FO LE. | ca |
dc.format.extent | 26 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.publisher | Cambridge University Press (CUP) | ca |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1017/S0007114520000574 | - |
dc.relation.ispartof | British Journal of Nutrition, 2020, vol. 123, num. 12, p. 1365-1372 | - |
dc.relation.uri | https://doi.org/10.1017/S0007114520000574 | - |
dc.rights | (c) Llop Talaveron et al., 2020 | - |
dc.source | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) | - |
dc.subject.classification | Lípids de la sang | - |
dc.subject.classification | Fitosterols | - |
dc.subject.other | Blood lipids | - |
dc.subject.other | Phytosterols | - |
dc.title | Phytosterolemia associated with parenteral nutrition administration in adult patients | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.date.updated | 2020-02-27T09:22:59Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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2020_Br J Nutr.pdf | 622.08 kB | Adobe PDF | View/Open |
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