Please use this identifier to cite or link to this item:
Title: Prenatal air pollution exposure and growth and cardio-metabolic risk in preschoolers
Author: Fossati, Serena
Valvi, Damaskini
Martínez, David
Cirach, Marta
Estarlich, Marisa
Fernández Somoano, Ana
Guxens, Mònica
Iñiguez, Carmen
Irizar, Amaia
Lertxundi, Aitana
Nieuwenhuijsen, Mark J.
Tamayo Uria, Ibon
Vioque, Jesús
Tardón, Adonina
Sunyer Deu, Jordi
Vrijheid, Martine
Keywords: Malalties neonatals
Neonatal diseases
Issue Date: May-2020
Publisher: Elsevier Ltd
Abstract: -Objectives: We investigated the association between outdoor air pollutants exposure in the first trimester of preg- nancy, and growth and cardio-metabolic risk at four years of age, and evaluated the mediating role of birth weight. Methods: We included mother-child pairs (N = 1,724) from the Spanish INMA birth cohort established in 2003–2008. First trimester of pregnancy nitrogen dioxide (NO2) and fine particles (PM2.5) exposure levels were estimated. Height, weight, waist circumference, blood pressure, and lipids were measured at four years of age. Body mass index (BMI) trajectories from birth to four years were identified. Results: Increased PM2.5 exposure in the first trimester of pregnancy was associated with decreased z-scores of weight (zWeight) and BMI (zBMI) (zWeight change per interquartile range increase in PM2.5 exposure = −0.12; 95% CI: −0.23, −0.01; zBMI change = −0.12; 95% CI: −0.23, −0.01). Higher NO2 and PM2.5 exposure was associated to a reduced risk of being in a trajectory with accelerated BMI gain, compared to children with the average trajectory. Birth weight partially mediated the association between PM2.5 and zWeight and zBMI. PM2.5 and NO2 were not associated with the other cardio-metabolic risk factors. Conclusions: This comprehensive study of many growth and cardio-metabolic risk related outcomes suggests that air pollution exposure during pregnancy may be associated with delays in physical growth in the early years after birth. These findings imply that pregnancy exposure to air pollutants has a lasting effect on growth after birth and require follow-up at later child ages.
Note: Reproducció del document publicat a: 10.1016/j.envint.2020.105619
It is part of: Environment International, 2020, vol. 138, p. 105619
Related resource:
ISSN: 0160-4120
Appears in Collections:Articles publicats en revistes (ISGlobal)

Files in This Item:
File Description SizeFormat 
Fossati_S_Environ_Int_2020.pdf589.02 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons