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http://hdl.handle.net/2445/159721
Title: | Developmental and Tumor Angiogenesis Requires the Mitochondria-Shaping Protein Opa1 |
Author: | Herkenne, Stéphanie Ek, Olivier Zamberlan, Margherita Pellattiero, Anna Chergova, Maya Chivite, Íñigo Novotná, Eliška Rigoni, Giovanni Fonseca, Tiago Branco Samardzic, Dijana Agnellini, Andrielly Bean, Camilla Di Benedetto, Giulietta Tiso, Natascia Argenton, Francesco Viola, Antonella Soriano, Maria Eugenia Giacomello, Marta Ziviani, Elena Sales, Gabriele Claret i Carles, Marc Graupera i Garcia-Milà, Mariona Scorrano, Luca |
Keywords: | Angiogènesi Càncer Mitocondris Neovascularization Cancer Mitochondria |
Issue Date: | 5-May-2020 |
Publisher: | Elsevier BV |
Abstract: | While endothelial cell (EC) function is influenced by mitochondrial metabolism, the role of mitochondrial dynamics in angiogenesis, the formation of new blood vessels from existing vasculature, is unknown. Here we show that the inner mitochondrial membrane mitochondrial fusion protein optic atrophy 1 (OPA1) is required for angiogenesis. In response to angiogenic stimuli, OPA1 levels rapidly increase to limit nuclear factor kappa-light-chain-enhancer of activated B cell (NFκB) signaling, ultimately allowing angiogenic genes expression and angiogenesis. Endothelial Opa1 is indeed required in an NFκB-dependent pathway essential for developmental and tumor angiogenesis, impacting tumor growth and metastatization. A first-in-class small molecule-specific OPA1 inhibitor confirms that EC Opa1 can be pharmacologically targeted to curtail tumor growth. Our data identify Opa1 as a crucial component of physiological and tumor angiogenesis. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.cmet.2020.04.007 |
It is part of: | Cell Metabolism, 2020, vol. 31, num. 5, p. 987-1003 |
URI: | http://hdl.handle.net/2445/159721 |
Related resource: | https://doi.org/10.1016/j.cmet.2020.04.007 |
Appears in Collections: | Comunicacions a congressos (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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