Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/159963
Title: | Kindlin-2 controls bidirectional signaling of integrins. |
Author: | Montañez, Eloi Ussar, Siegfried Schifferer, Martina Bösl, Michael Zent, Roy Moser, Markus Fässler, Reinhard |
Keywords: | Proteïnes citosquelètiques Integrines Metabolisme Cytoskeletal proteins Integrins Metabolism |
Issue Date: | 15-May-2008 |
Publisher: | Cold Spring Harbor Laboratory Press |
Abstract: | Control of integrin activation is required for cell adhesion and ligand-induced signaling. Here we report that loss of the focal adhesion protein Kindlin-2 in mice results in peri-implantation lethality caused by severe detachment of the endoderm and epiblast from the basement membrane. We found that Kindlin-2-deficient cells were unable to activate their integrins and that Kindlin-2 is required for talin-induced integrin activation. Furthermore, we demonstrate that Kindlin-2 is required for integrin outside-in signaling to enable firm adhesion and spreading. Our findings provide evidence that Kindlin-2 is a novel and essential element of bidirectional integrin signaling. |
Note: | Reproducció del document publicat a: https://doi.org/10.1101/gad.469408 |
It is part of: | Genes & Development, 2008, vol. 22, num. 10, p. 1325-1330 |
URI: | http://hdl.handle.net/2445/159963 |
Related resource: | https://doi.org/10.1101/gad.469408 |
ISSN: | 0890-9369 |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
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699438.pdf | 498.35 kB | Adobe PDF | View/Open |
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