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http://hdl.handle.net/2445/160534
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DC Field | Value | Language |
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dc.contributor.author | Gianesin, Ketty | - |
dc.contributor.author | Noguera Julian, Antoni | - |
dc.contributor.author | Zanchetta, Marisa | - |
dc.contributor.author | Del Bianco, Paola | - |
dc.contributor.author | Petrara, Maria Raffaella | - |
dc.contributor.author | Freguja, Riccardo | - |
dc.contributor.author | Rampon, Osvalda | - |
dc.contributor.author | Fortuny Guasch, Claudia | - |
dc.contributor.author | Camós Guijosa, Mireia | - |
dc.contributor.author | Mozzo, Elena | - |
dc.contributor.author | Giaquinto, Carlo | - |
dc.contributor.author | De Rossi, Anita | - |
dc.date.accessioned | 2020-05-15T12:24:47Z | - |
dc.date.available | 2020-05-15T12:24:47Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0269-9370 | - |
dc.identifier.uri | http://hdl.handle.net/2445/160534 | - |
dc.description.abstract | Objective: Several pieces of evidence indicate that HIV-infected adults undergo premature aging. The effect of HIV and antiretroviral therapy (ART) exposure on the aging process of HIV-infected children may be more deleterious since their immune system coevolves from birth with HIV. Design: Seventy-one HIV-infected (HIV+), 65 HIV-exposed-uninfected (HEU), and 56 HIV-unexposed-uninfected (HUU) children, all aged 0-5 years, were studied for biological aging and immune senescence. Methods: Telomere length and T-cell receptor rearrangement excision circle levels were quantified in peripheral blood cells by real-time PCR. CD4+ and CD8+ cells were analysed for differentiation, senescence, and activation/exhaustion markers by flow cytometry. Results: Telomere lengths were significantly shorter in HIV+ than in HEU and HUU children (overall, P < 0.001 adjusted for age); HIV+ ART-naive (42%) children had shorter telomere length compared with children on ART (P = 0.003 adjusted for age). T-cell receptor rearrangement excision circle levels and CD8+ recent thymic emigrant cells (CD45RA+CD31+) were significantly lower in the HIV+ than in control groups (overall, P = 0.025 and P = 0.005, respectively). Percentages of senescent (CD28−CD57+), activated (CD38+HLA-DR+), and exhausted (PD1+) CD8+ cells were significantly higher in HIV+ than in HEU and HUU children (P = 0.004, P < 0.001, and P < 0.001, respectively). Within the CD4+ cell subset, the percentage of senescent cells did not differ between HIV+ and controls, but programmed cell death receptor-1 expression was upregulated in the former. Conclusions: HIV-infected children exhibit premature biological aging with accelerated immune senescence, which particularly affects the CD8+ cell subset. HIV infection per se seems to influence the aging process, rather than exposure to ART for prophylaxis or treatment. Keywords: immune activation, immune senescence, microbial translocation, pediatric HIV/AIDS, premature aging, telomere length, T-cell receptor rearrangement excision circle | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Lippincott, Williams & Wilkins | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1097/QAD.0000000000001093 | - |
dc.relation.ispartof | AIDS, 2016 | - |
dc.relation.uri | https://doi.org/10.1097/QAD.0000000000001093 | - |
dc.rights | cc by-nc-nd (c) Lippincott, Williams & Wilkins, 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Sida en els infants | - |
dc.subject.classification | Medicaments | - |
dc.subject.classification | Envelliment | - |
dc.subject.other | AIDS (Disease) in children | - |
dc.subject.other | Drugs | - |
dc.subject.other | Aging | - |
dc.title | Premature aging and immune senescence in HIV-infected children. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 668927 | - |
dc.date.updated | 2020-05-15T12:24:47Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/260694/EU//EUROCOORD | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 26990630 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Publicacions de projectes de recerca finançats per la UE |
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668927.pdf | 370.5 kB | Adobe PDF | View/Open |
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