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Title: Diagnostic Accuracy, Item Analysis and Age Effects of the UPSIT Spanish Version in Parkinson's Disease
Author: Campabadal, Anna
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Abós, Alexandra
Uribe, Carme
García Díaz, Anna I.
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Compta, Yaroslau
Bargalló Alabart, Núria​
Junqué i Plaja, Carme, 1955-
Keywords: Malaltia de Parkinson
Malalties neurodegeneratives
Parkinson's disease
Neurodegenerative Diseases
Issue Date: 1-Jun-2019
Publisher: Oxford University Press
Abstract: Objective The University of Pennsylvania Smell Identification Test (UPSIT) is the most commonly used test to detect olfactory impairment in Parkinson's disease (PD), but the cut-off score for clinical purposes is often difficult to establish because of age and sex effects. The current work aims to study the sensitivity and specificity of the UPSIT Spanish version and its accuracy in discriminating PD patients at different age groups from healthy controls (HC), and to perform an item analysis. Method Ninety-seven non-demented PD patients and 65 HC were assessed with the UPSIT Spanish version. Sensitivity, specificity, and diagnostic accuracy for PD were calculated. Multiple regression analysis was used to define predictors of UPSIT scores. Results Using the normative cut-off score for anosmia (≤18), the UPSIT showed a sensitivity of 54.6% with a specificity of 100.0% for PD. We found that, using the UPSIT cut-off score of ≤25, sensitivity was 81.4% and specificity 84.6% (area under the receiver operating characteristic curve = 0.908). Diagnosis and age were good predictors of UPSIT scores (B = −10.948; p < .001; B = −0.203; p < .001). When optimal cut-off scores were considered according to age ranges (≤60, 61-70, and ≥71), sensitivity and specificity values were >80.0% for all age groups. Conclusions In the Spanish UPSIT version, sensitivity and specificity are improved when specific cut-off scores for different age groups are computed.
Note: Versió postprint del document publicat a:
It is part of: Archives of Clinical Neuropsychology, 2019, vol. 34, num. 4, p. 435-444
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ISSN: 0887-6177
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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