Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/161625
Title: | Neuroanatomical correlates of olfactory loss in normal aged subjects |
Author: | Segura i Fàbregas, Bàrbara Baggio, Hugo César Solana Díaz, Elisabeth Palacios, Eva M. Vendrell i Gómez, Pere Bargalló Alabart, Núria Junqué i Plaja, Carme, 1955- |
Keywords: | Olfacte Imatges per ressonància magnètica Psiquiatria Smell Magnetic resonance imaging Psychiatry |
Issue Date: | 1-Jun-2013 |
Publisher: | Elsevier B.V. |
Abstract: | In non-demented older persons, smell dysfunction, measured premortem, has been associated with postmortem brain degeneration similar to that of Alzheimer's disease. We hypothesized that distinct measures of gray and white matter integrity evaluated through magnetic resonance imaging (MRI) techniques could detect degenerative changes associated with age-related olfactory dysfunction. High-resolution T1-weighted images and diffusion-tensor images (DTI) of 30 clinically healthy subjects aged 51 to 77 were acquired with a 3-Tesla MRI scanner. Odor identification performance was assessed by means of the University of Pennsylvania Smell Identification Test (UPSIT). UPSIT scores correlated with right amygdalar volume and bilateral perirhinal and entorhinal cortices gray matter volume. Olfactory performance also correlated with postcentral gyrus cortical thickness and with fractional anisotropy and mean diffusivity levels in the splenium of the corpus callosum and the superior longitudinal fasciculi. Our results suggest that age-related olfactory loss is accompanied by diffuse degenerative changes that might correspond to the preclinical stages of neurodegenerative processes. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.bbr.2013.02.025 |
It is part of: | Behavioural Brain Research, 2013, vol. 246, p. 148-153 |
URI: | http://hdl.handle.net/2445/161625 |
Related resource: | https://doi.org/10.1016/j.bbr.2013.02.025 |
ISSN: | 0166-4328 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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