Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/161737
Títol: Metal-based nanoparticles as antimicrobial agents: an overview.
Autor: Sánchez-López, E. (Elena)
Gomes, Daniela
Esteruelas Navarro, Gerard
Bonilla Vidal, Lorena
López-Machado, Ana
Galindo Camacho, Ruth Milagros
Cano Fernández, Amanda
Espina García, Marta
Ettcheto Arriola, Miren
Camins Espuny, Antoni
Silva, Amélia M.
Durazzo, Alessandra
Santini, Antonello
García López, María Luisa
Souto, Eliana B.
Matèria: Nanopartícules
Metalls
Bacteris
Nanoparticles
Metals
Bacteria
Data de publicació: 9-feb-2020
Publicat per: MDPI
Resum: Metal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have also proved to be effective against pathogens listed as a priority. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms (they do not bind to a specific receptor in the bacterial cell) which not only makes the development of resistance by bacteria difficult, but also broadens the spectrum of antibacterial activity. As a result, a large majority of metal-based nanoparticles efficacy studies performed so far have shown promising results in both Gram-positive and Gram-negative bacteria. The aim of this review has been a comprehensive discussion of the state of the art on the use of the most relevant types of metal nanoparticles employed as antimicrobial agents. A special emphasis to silver nanoparticles is given, while others (e.g., gold, zinc oxide, copper, and copper oxide nanoparticles) commonly used in antibiotherapy are also reviewed. The novelty of this review relies on the comparative discussion of the different types of metal nanoparticles, their production methods, physicochemical characterization, and pharmacokinetics together with the toxicological risk encountered with the use of different types of nanoparticles as antimicrobial agents. Their added Metal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have also proved to be effective against pathogens listed as a priority. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms (they do not bind to a specific receptor in the bacterial cell) which not only makes the development of resistance by bacteria difficult, but also broadens the spectrum of antibacterial activity. As a result, a large majority of metal-based nanoparticles efficacy studies performed so far have shown promising results in both Gram-positive and Gram-negative bacteria. The aim of this review has been a comprehensive discussion of the state of the art on the use of the most relevant types of metal nanoparticles employed as antimicrobial agents. A special emphasis to silver nanoparticles is given, while others (e.g., gold, zinc oxide, copper, and copper oxide nanoparticles) commonly used in antibiotherapy are also reviewed. The novelty of this review relies on the comparative discussion of the different types of metal nanoparticles, their production methods, physicochemical characterization, and pharmacokinetics together with the toxicological risk encountered with the use of different types of nanoparticles as antimicrobial agents. Their added
Nota: Reproducció del document publicat a: https://doi.org/10.3390/nano10020292
És part de: Nanomaterials, 2020, vol. 10, p. 292
URI: https://hdl.handle.net/2445/161737
Recurs relacionat: https://doi.org/10.3390/nano10020292
ISSN: 2079-4991
Apareix en les col·leccions:Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

Fitxers d'aquest document:
Fitxer Descripció DimensionsFormat 
699280.pdf1.15 MBAdobe PDFMostrar/Obrir


Aquest document està subjecte a una Llicència Creative Commons Creative Commons