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Title: The proangiogenic potential of a novel calcium releasing biomaterial: Impact on cell recruitment
Author: Oliveira, Hugo
Catros, Sylvain
Boiziau, Claudine
Siadous, Robin
Martí Muñoz, Joan
Bareille, Reine
Rey, Sylvie
Castaño Linares, Óscar
Plane, Josep
Amédée, Joelle
Engel, Elisabeth
Keywords: Regeneració (Biologia)
Regeneration (Biology)
Issue Date: 1-Jan-2016
Publisher: Elsevier B.V.
Abstract: In current bone tissue engineering approaches the achievement of sufficient angiogenesis, during tissue regeneration, is a major limitation in order to attain full tissue functionality. Recently, our group has found that calcium ions released by the degradation of calcium phosphate ormoglasses (CaP) are effective angiogenic promoters. Based on this, in this work we successfully produced hybrid fibrous mats with different contents of CaP nanoparticles and thus with different calcium ion release rates, using an ormoglass - poly(lactic acid) blend approach. We show that these matrices, upon implantation in a subcutaneous site, could elicit the local expression of angiogenic factors, associated to a chemotactic effect on macrophages, and sustained angiogenesis into the biomaterial, in a CaP dose dependent manner. This off-the-shelf cost effective approach presents great potential to translate to the clinics. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Note: Versió postprint del document publicat a:
It is part of: Acta Biomaterialia, 2016, vol. 29, p. 435-445
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ISSN: 1742-7061
Appears in Collections:Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)

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