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Title: | Estimation of the octanol-water distribution coefficient of basic compounds by a cationic microemulsion electrokinetic chromatography system |
Author: | Fernández-Pumarega, Alejandro. Martín Sanz, Belén Amézqueta, Susana Fuguet i Jordà, Elisabet Rosés Pascual, Martí |
Keywords: | Cromatografia Micel·les Chromatography Micelles |
Issue Date: | 11-Nov-2019 |
Publisher: | IAPC Publishing |
Abstract: | The octanol-water partition coefficient (Po/w), or the octanol-water distribution coefficient (Do/w) for ionized compounds, is a key parameter in the drug development process. In a previous work, this parameter was estimated through the retention factor measurements in a sodium dodecyl sulfate (SDS) - microemulsion electrokinetic chromatography (MEEKC) system for acidic compounds. Nonetheless, when ionized basic compounds were analyzed, undesirable ion pairs were formed with the anionic surfactant and avoided a good estimation of log Do/w. For this reason, an alternative MEEKC system based on a cationic surfactant has been evaluated to estimate Po/w or Do/w of neutral compounds and ionized bases. To this end, it has been characterized through the solvation parameter model (SPM) and compared to the octanol-water partition system. Results pointed out that both systems show a similar partition behavior. Hence, the log Po/w of a set of neutral compounds has been successfully correlated against the logarithm of the retention factor (log k) determined in this MEEKC system. Then, the log Do/w of 6 model bases have been estimated at different pH values and they have been compared to data from the literature, determined by the reference shake-flask and potentiometric methods. Good agreement has been observed between the literature and the estimated values when the base is neutral or partially ionized (up to 99 % of ionization). |
Note: | Reproducció del document publicat a: https://doi.org/10.5599/admet.760 |
It is part of: | ADMET & DMPK, 2019, vol. 179, p. 112981-112981 |
URI: | http://hdl.handle.net/2445/162213 |
Related resource: | https://doi.org/10.5599/admet.760 |
ISSN: | 1848-7718 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
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