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http://hdl.handle.net/2445/162279
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DC Field | Value | Language |
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dc.contributor.author | Amézqueta, Susana | - |
dc.contributor.author | Ramos Romero, Sara | - |
dc.contributor.author | Martínez-Guimet, C. | - |
dc.contributor.author | Moreno, Albert | - |
dc.contributor.author | Hereu, Mercè | - |
dc.contributor.author | Torres Simón, Josep Lluís | - |
dc.date.accessioned | 2020-05-25T12:21:38Z | - |
dc.date.available | 2020-05-25T12:21:38Z | - |
dc.date.issued | 2017-05-10 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | http://hdl.handle.net/2445/162279 | - |
dc.description.abstract | D-Fagomine is an iminosugar found in buckwheat that is capable of inhibiting the adhesion of potentially pathogenic bacteria to epithelial mucosa and of reducing postprandial blood glucose concentration. This paper evaluates the excretion and metabolism of orally administered D-fagomine in rats and compares outcomes with the fate of 1-deoxynojirimycin. D-Fagomine and 1- deoxynojirimycin show similar absorption and excretion kinetics. D-Fagomine is partly absorbed (41-84%, dose 2 mg/kg body weight) and excreted in urine within 8 h while non-absorbed fraction is cleared in feces within 24 h. D-Fagomine is partially methylated (about 10% in urine and 3% in feces). The concentration of D-fagomine in urine from 1 to 6 h after administration is higher than 10 mg/L, the concentration that inhibits adhesion of Escherichia coli. Orally administered D-fagomine is partially absorbed and then rapidly excreted in urine were it reaches a concentration that may be protective against urinary tract infections. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/acs.jafc.7b01026 | - |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry, 2017, vol. 65, num. 22, p. 4414-4420 | - |
dc.relation.uri | https://doi.org/10.1021/acs.jafc.7b01026 | - |
dc.rights | (c) American Chemical Society , 2017 | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Glucòsids | - |
dc.subject.classification | Infeccions per escheríchia coli | - |
dc.subject.classification | Infeccions del tracte urinari | - |
dc.subject.other | Glucosides | - |
dc.subject.other | Escherichia coli infections | - |
dc.subject.other | Urinary tract infections | - |
dc.title | Fate of d‑fagomine after oral administration to rats | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 671782 | - |
dc.date.updated | 2020-05-25T12:21:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
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671782.pdf | 373.27 kB | Adobe PDF | View/Open |
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