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http://hdl.handle.net/2445/162326
Title: | The buckwheat iminosugar d-fagomine attenuates sucrose-induced steatosis and hypertension in rats |
Author: | Ramos Romero, Sara Hereu, Mercè Atienza, Lidia Amézqueta, Susana Casas, Josefina Muñoz, Silvia Medina, Isabel Miralles-Pérez, Bernat Romeu Ferran, Marta Torres, Josep Lluís |
Keywords: | Metagenòmica Obesitat Diabetis Pressió sanguínia Metagenomics Obesity Diabetes Blood pressure |
Issue Date: | 28-Oct-2019 |
Publisher: | Wiley-VCH |
Abstract: | Scope: This study examines the long-term functional effects of D-fagomine on sucrose4 induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods & results: Wistar Kyoto (WKY) rats were fed a 35% sucrose solution with D- fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. We recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F2t isoprostanes (F2-IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. D-Fagomine reduced sucrose-induced hypertension, urine uric acid and F2-IsoPs (markers of oxidative stress; OS), steatosis and liver DAGs, without significantly affecting perigonadal fat deposition and impaired glucose tolerance. It also promoted excretion of enterobacteriales generated by the dietary intervention. Conclusion: D-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.201900564 |
It is part of: | Molecular Nutrition & Food Research, 2019, vol. 64, num. 1, p. 1900564-1900564 |
URI: | http://hdl.handle.net/2445/162326 |
Related resource: | https://doi.org/10.1002/mnfr.201900564 |
ISSN: | 1613-4125 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
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