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http://hdl.handle.net/2445/162418
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DC Field | Value | Language |
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dc.contributor.author | Baggio, Hugo César | - |
dc.contributor.author | Segura i Fàbregas, Bàrbara | - |
dc.contributor.author | Garrido Millan, J.L. | - |
dc.contributor.author | Martí Domènech, Ma. Josep | - |
dc.contributor.author | Compta, Yaroslau | - |
dc.contributor.author | Valldeoriola Serra, Francesc | - |
dc.contributor.author | Tolosa, Eduardo | - |
dc.contributor.author | Junqué i Plaja, Carme, 1955- | - |
dc.date.accessioned | 2020-05-26T10:01:31Z | - |
dc.date.available | 2020-05-26T10:01:31Z | - |
dc.date.issued | 2015-04-15 | - |
dc.identifier.issn | 0885-3185 | - |
dc.identifier.uri | http://hdl.handle.net/2445/162418 | - |
dc.description.abstract | Background: One of the most common neuropsychiatric symptoms in PD is apathy, affecting between 23 and 70% of patients and thought to be related to frontostriatal dopamine deficits. In the present study, we assessed functional resting-state frontostriatal connectivity and structural changes associated with the presence of apathy in a large sample of PD subjects and healthy controls, while controlling for the presence of comorbid depression and cognitive decline. Methods: Thirty-one healthy controls (HC) and 62 age, sex and education-matched PD patients underwent resting-state functional MRI. Apathy symptoms were evaluated with the Apathy Scale (AS). The 11 Beck Depression Inventory-II items that measure dysphoric mood symptoms as well as relevant neuropsychological scores were used as nuisance factors in connectivity analyses. Voxel-wise analyses of functional connectivity between frontal lobes (limbic, executive, rostral motor and caudal motor regions), striata (limbic, executive, sensorimotor regions) and thalami were performed. Subcortical volumetry/shape analysis and fronto-subcortical voxel-based morphometry were performed to assess structural changes. Results: Twenty-five PD patients were classified as apathetic (PD-A) (AS>13). PD-A patients showed functional connectivity reductions compared with HC and with non-apathetic patients (PD-NA), mainly in left-sided circuits, and predominantly involving limbic striatal and frontal territories. Similarly, severity of apathy negatively correlated with connectivity in these circuits. No significant effects were found in structural analyses. Conclusions: Our results indicate that the presence of apathy in PD is associated with functional connectivity reductions in frontostriatal circuits, predominating in the left hemisphere and mainly involving its limbic components. | - |
dc.format.extent | 26 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/mds.26137 | - |
dc.relation.ispartof | Movement Disorders, 2015, vol. 30, num. 5, p. 671-679 | - |
dc.relation.uri | https://doi.org/10.1002/mds.26137 | - |
dc.rights | (c) International Parkinson and Movement Disorder Society, 2015 | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Neuropsicologia | - |
dc.subject.classification | Imatges per ressonància magnètica | - |
dc.subject.classification | Malaltia de Parkinson | - |
dc.subject.other | Neuropsychology | - |
dc.subject.other | Magnetic resonance imaging | - |
dc.subject.other | Parkinson's disease | - |
dc.title | Resting-state frontostriatal functional connectivity in Parkinson's disease-related apathy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 647970 | - |
dc.date.updated | 2020-05-26T10:01:31Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25600482 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
Files in This Item:
File | Description | Size | Format | |
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647970.pdf | 686.19 kB | Adobe PDF | View/Open |
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