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Title: Cognitive impairment and resting-state network connectivity in Parkinson's disease
Author: Baggio, Hugo César
Segura i Fàbregas, Bàrbara
Sala Llonch, Roser
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Compta, Yaroslau
Tolosa, Eduardo
Junqué i Plaja, Carme, 1955-
Keywords: Neuropsicologia
Malaltia de Parkinson
Imatges per ressonància magnètica
Parkinson's disease
Magnetic resonance imaging
Issue Date: 28-Jan-2015
Publisher: Wiley
Abstract: Previous functional MRI studies have revealed changes in the default-mode network (DMN) in Parkinson's disease (PD). The purpose of this work was to evaluate changes in the connectivity patterns of a set of cognitively relevant, dynamically interrelated brain networks in association with cognitive deficits in PD using resting-state functional MRI. Sixty-five non-demented PD patients and 36 matched healthy controls (HC) were included. Thirty-four percent of PD patients were classified as having mild cognitive impairment (MCI) based on performance in the three mainly-affected cognitive domains in Parkinson's disease (attention/executive, visuospatial/visuoperceptual and declarative memory). Data-driven analyses through independent-component analysis (ICA) was used to identify the DMN, the dorsal attention network (DAN) and the bilateral frontoparietal networks (FPN), which were compared between groups using a dual-regression approach. Additional seed-based analyses using a-priori defined regions of interest were used to characterize local changes in intra and inter-network connectivity. ICA results revealed reduced connectivity between the DAN and right frontoinsular cortical regions in MCI patients, which correlated with worse performance in attention/executive functions. The DMN, on the other hand, displayed increased connectivity with medial and lateral occipito-parietal regions in MCI patients; these increases correlated with worse visuospatial/visuoperceptual performance. In line with data-driven results, seed-based analyses mainly revealed reduced within-DAN, within-DMN and DAN-FPN connectivity, as well as increased DAN-DMN coupling in MCI patients. Our findings demonstrate differential connectivity changes affecting the networks evaluated, which we hypothesize to be related to the pathophysiological bases of different types of cognitive impairment in PD.
Note: Versió postprint del document publicat a:
It is part of: Human Brain Mapping, 2015, vol. 36, num. 1, p. 199-212
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ISSN: 1065-9471
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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