Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/162423
Title: Functional brain networks and cognitive deficits in Parkinson's disease
Author: Baggio, Hugo César
Sala Llonch, Roser
Segura i Fàbregas, Bàrbara
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Compta, Yaroslau
Tolosa, Eduardo
Junqué i Plaja, Carme, 1955-
Keywords: Neuropsicologia
Malaltia de Parkinson
Xarxes neuronals (Neurobiologia)
Imatges per ressonància magnètica
Neuropsychology
Parkinson's disease
Neural networks (Neurobiology)
Magnetic resonance imaging
Issue Date: 17-Mar-2014
Publisher: Wiley
Abstract: Abstract: Graph-theoretical analyses of functional networks obtained with resting-state functional mag-netic resonance imaging (fMRI) have recently proven to be a useful approach for the study of the sub-strates underlying cognitive deficits in different diseases. We used this technique to investigate whethercognitive deficits in Parkinson's disease (PD) are associated with changes in global and local networkmeasures. Thirty-six healthy controls (HC) and 66 PD patients matched for age, sex, and education wereclassified as having mild cognitive impairment (MCI) or not based on performance in the three mainlyaffected cognitive domains in PD: attention/executive, visuospatial/visuoperceptual (VS/VP), anddeclarative memory. Resting-state fMRI and graph theory analyses were used to evaluate network meas-ures. We have found that patients with MCI had connectivity reductions predominantly affecting long-range connections as well as increased local interconnectedness manifested as higher measures of cluster-ing, small-worldness, and modularity. The latter measures also tended to correlate negatively with cogni-tive performance in VS/VP and memory functions. Hub structure was also reorganized: normal hubsdisplayed reduced centrality and degree in MCI PD patients. Our study indicates that the topologicalproperties of brain networks are changed in PD patients with cognitive deficits. Our findings providenovel data regarding the functional substrate of cognitive impairment in PD, which may prove to havevalue as a prognostic marker.
Note: Versió postprint del document publicat a: https://doi.org/10.1002/hbm.22499
It is part of: Human Brain Mapping, 2014, vol. 35, num. 9, p. 4620-4634
URI: https://hdl.handle.net/2445/162423
Related resource: https://doi.org/10.1002/hbm.22499
ISSN: 1065-9471
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
635419.pdf4.19 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.