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Title: Statin use and the risk of colorectal cancer in a population-based electronic health records study
Author: Ibáñez-Sanz, Gemma
Guinó, Elisabet
Pontes, Caridad
Quijada Manuitt, M. Angeles
de la Peña-Negro, LuisaC
Aragón, María
Domínguez, Marga
Rodríguez Alonso, Lorena
Blasco, Alex
García-Rodríguez, Ana
Morros Pedrós, Rosa
Moreno Aguado, Víctor
Keywords: Càncer colorectal
Colorectal cancer
Issue Date: 19-Sep-2019
Publisher: Nature Publishing Group
Abstract: There is extensive debate regarding the protective effect of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) on colorectal cancer (CRC). We aimed to assess the association between CRC risk and exposure to statins using a large cohort with prescription data. We carried out a case-control study in Catalonia using the System for Development of Primary Care Research (SIDIAP) database that recorded patient diseases history and linked data on reimbursed medication. The study included 25 811 cases with an incident diagnosis of CRC between 2010 and 2015 and 129 117 frequency-matched controls. Subjects were classified as exposed to statins if they had ever been dispensed statins. Analysis considering mean daily defined dose, cumulative duration and type of statin were performed. Overall, 66 372 subjects (43%) were exposed to statins. There was no significant decrease of CRC risk associated to any statin exposure (OR = 0.98; 95% CI: 0.95-1.01). Only in the stratified analysis by location a reduction of risk for rectal cancer was observed associated to statin exposure (OR = 0.87; 95% CI: 0.81-0.92). This study does not support an overall protective effect of statins in CRC, but a protective association with rectal cancer merits further research.
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It is part of: Scientific Reports, 2019, vol. 9, p. 13560
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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