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Title: Corpora amylacea act as containers that remove waste products from the brain
Author: Riba Baqués, Marta
Augé Marí, Elisabet
Campo Sabariz, Joan
Moral Anter, David
Molina Porcel, Laura
Ximelis, Teresa
Ferrer i Roig, Ruth
Martín Venegas, Raquel
Pelegrí i Gabaldà, Carme
Vilaplana i Hortensi, Jordi
Keywords: Envelliment
Malalties neurodegeneratives
Sistema limfàtic
Sistema immunitari
Neurodegenerative Diseases
Immune system
Issue Date: 3-Dec-2019
Publisher: National Academy of Sciences
Abstract: Corpora amylacea (CA) in the human brain are granular bodies formed by polyglucosan aggregates that amass waste products of different origins. They are generated by astrocytes, mainly during aging and neurodegenerative conditions, and are located predominantly in periventricular and subpial regions. This study shows that CA are released from these regions to the cerebrospinal fluid and are present in the cervical lymph nodes, into which cerebrospinal fluid drains through the meningeal lymphatic system. We also show that CA can be phagocytosed by macrophages. We conclude that CA can act as containers that remove waste products from the brain and may be involved in a mechanism that cleans the brain. Moreover, we postulate that CA may contribute in some autoimmune brain diseases, exporting brain substances that interact with the immune system, and hypothesize that CA may contain brain markers that may aid in the diagnosis of certain brain diseases.
Note: Versió postprint del document publicat a:
It is part of: Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2019, vol. 116, num. 51, p. 26038-26048
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ISSN: 0027-8424
Appears in Collections:Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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