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https://hdl.handle.net/2445/162821| Title: | Total Synthesis of the Brdged Indole Alkaloid Apparicine |
| Author: | Bennasar Fèlix, M. Lluïsa Zulaica Gallego, Ester Solé Arjó, Daniel Roca Estrem, Tomàs García Díaz, Davinia Alonso Serrano, Sandra |
| Keywords: | Síntesi orgànica Alcaloides Metàtesi (Química) Organic synthesis Alkaloids Metathesis (Chemistry) |
| Issue Date: | 14-Oct-2009 |
| Publisher: | American Chemical Society |
| Abstract: | An indole-templated ring-closing metathesis or a 2-indolylacyl radical cyclization constitute the central steps of two alternative approaches developed to assemble the tricyclic ABC substructure of the indole alkaloid apparicine. From this key intermediate, an intramolecular vinyl halide Heck reaction accomplished the closure of the strained 1-azabicyclo[4.2.2]decane framework of the alkaloid with concomitant incorporation of the exocyclic alkylidene substituents. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1021/jo901986v |
| It is part of: | Journal of Organic Chemistry, 2009, vol. 74, p. 8359-8368 |
| URI: | https://hdl.handle.net/2445/162821 |
| Related resource: | https://doi.org/10.1021/jo901986v |
| ISSN: | 0022-3263 |
| Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 571603.pdf | 1.18 MB | Adobe PDF | View/Open |
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