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Title: Total Synthesis of the Brdged Indole Alkaloid Apparicine
Author: Bennasar Fèlix, M. Lluïsa
Zulaica Gallego, Ester
Solé Arjó, Daniel
Roca Estrem, Tomàs
García Díaz, Davinia
Alonso Serrano, Sandra
Keywords: Síntesi orgànica
Metàtesi (Química)
Organic synthesis
Metathesis (Chemistry)
Issue Date: 14-Oct-2009
Publisher: American Chemical Society
Abstract: An indole-templated ring-closing metathesis or a 2-indolylacyl radical cyclization constitute the central steps of two alternative approaches developed to assemble the tricyclic ABC substructure of the indole alkaloid apparicine. From this key intermediate, an intramolecular vinyl halide Heck reaction accomplished the closure of the strained 1-azabicyclo[4.2.2]decane framework of the alkaloid with concomitant incorporation of the exocyclic alkylidene substituents.
Note: Versió postprint del document publicat a:
It is part of: Journal of Organic Chemistry, 2009, vol. 74, p. 8359-8368
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ISSN: 0022-3263
Appears in Collections:Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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