Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/162874
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Barbas Cañero, Rafael | - |
dc.contributor.author | Font Bardia, Ma. Mercedes | - |
dc.contributor.author | Paradkar, A. | - |
dc.contributor.author | Hunter, C. A. | - |
dc.contributor.author | Prohens López, Rafael | - |
dc.date.accessioned | 2020-05-28T16:37:49Z | - |
dc.date.available | 2020-05-28T16:37:49Z | - |
dc.date.issued | 2018-10-30 | - |
dc.identifier.issn | 1528-7483 | - |
dc.identifier.uri | http://hdl.handle.net/2445/162874 | - |
dc.description.abstract | New multicomponent solid forms of sildenafil have been discovered by means of a combined virtual/experimental cocrystal screening. Coformer selection of candidates was conducted based on an in silico screening method from a database of more than 2000 organic compounds, and the intensive experimental screen produced 23 new solid forms. Since the 12 coformers chosen have a combination of phenol and carboxylic acid groups, a variety of cocrystals, salts, and hybrid salt-cocrystals were discovered and characterized. | - |
dc.format.extent | 39 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1021/acs.cgd.8b01413 | - |
dc.relation.ispartof | Crystal Growth & Design, 2018, vol. 18, num. 12, p. 7618-7627 | - |
dc.relation.uri | https://doi.org/10.1021/acs.cgd.8b01413 | - |
dc.rights | (c) American Chemical Society , 2018 | - |
dc.source | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) | - |
dc.subject.classification | Àcids orgànics | - |
dc.subject.classification | Sals | - |
dc.subject.classification | Estructura cristal·lina (Sòlids) | - |
dc.subject.other | Organic acids | - |
dc.subject.other | Salts | - |
dc.subject.other | Layer structure (Solids) | - |
dc.title | Combined Virtual/Experimental Multicomponent Solid Forms Screening of Sildenafil: New Salts, Cocrystals, and Hybrid Salt−Cocrystals | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 693054 | - |
dc.date.updated | 2020-05-28T16:37:49Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) |
Files in This Item:
File | Description | Size | Format | |
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693054.pdf | 2.38 MB | Adobe PDF | View/Open |
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