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Title: Polymorphism of Sildenafil: A New Metastable Desolvate
Author: Barbas Cañero, Rafael
Font Bardia, Ma. Mercedes
Prohens López, Rafael
Keywords: Estructura cristal·lina (Sòlids)
Layer structure (Solids)
Issue Date: 2018
Publisher: American Chemical Society
Abstract: A new anhydrous polymorph of the free base of sildenafil and two solvates (acetonitrile and propanenitrile) have been discovered and fully characterized. The new polymorph can be considered a desolvate of the acetonitrile solvate and is related to the most stable form I by morphotropism. The new polymorph can only be obtained by desolvation of the acetonitrile solvate. Thus, this study is a new example of the importance of this multicomponent family of solid forms in the discovery of new polymorphs of active pharmaceutical ingredients.
Note: Versió postprint del document publicat a:
It is part of: Crystal Growth & Design, 2018, vol. 18, num. 7, p. 3740-3746
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ISSN: 1528-7483
Appears in Collections:Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

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