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Title: DNA delivery via cationic solid lipid nanoparticles (SLNs)
Author: Carrillo Sánchez, Carolina
Sánchez Hernández, Noemí
García Montoya, Encarna
Pérez Lozano, Pilar
Ticó Grau, Josep R.
Suñé i Negre, Josep M. (Josep Maria)
Suñé, Carlos
Miñarro Carmona, Montserrat
Keywords: Dispositius d'administració de medicaments
Teràpia genètica
Drug delivery devices
Gene therapy
Issue Date: 27-Feb-2013
Publisher: Elsevier B.V.
Abstract: In recent years the use of solid lipid nanoparticles (SLNs) as transport systems for the delivery of drugs and biomolecules has become particularly important. The use of cationic SLNs developed by the technique of microemulsion, which are complexed with DNA in order to study their application as non-viral vectors in gene therapy, is reported. The nanoparticles are characterized by scanning electron microscopy and transmission electron microscopy (SEM and TEM), atomic force microscopy (AFM) and differential scanning calorimetry (DSC). Furthermore, the process of lyophilization of the samples and their stability was studied. The nanoparticles obtained presented a particle size of 340 nm with a positive surface charge of 44 mV and the capability of forming lipoplexes with DNA plasmids was stated.
Note: Versió postprint del document publicat a:
It is part of: European Journal of Pharmaceutical Sciences, 2013, vol. 49, num. 2, p. 157-165
Related resource:
ISSN: 0928-0987
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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