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Title: Lactic acidosis associated with metformin in patients with moderate to severe chronic kidney disease: study protocol for a multicenter population-based case-control study using health databases.
Author: Pedrós, Consuelo
Ávila, Mónica
Gómez-Lumbreras, Ainhoa
Manriquez, Marcela
Morros Pedrós, Rosa
Videla, Sebas
ALIMAR-C2 Study Group
Keywords: Metformina
Diabetis no-insulinodependent
Malalties del ronyó
Non-insulin-dependent diabetes
Kidney diseases
Issue Date: 30-May-2019
Publisher: BioMed Central
Abstract: Background: The use of metformin in patients with type 2 diabetes mellitus has been associated with lactic acidosis. However, the information available in patients with moderate-severe chronic kidney disease is scarce. Methods: The ALIMAR-C2 study is a case-control study to assess the association between metformin and lactic acidosis in patients with type 2 diabetes mellitus and moderate-severe chronic kidney disease. The study will be performed with computerized registered electronic health records from eight Spanish hospitals linked to their corresponding primary care health areas from 2010 to 2016, comprising approximately 22.1 million person-years of follow-up. Logistic regression will be used to assess the crude and adjusted risk of lactic acidosis associated with metformin use overall and stratifying by use and dose categories, and chronic kidney disease stage. The overall case fatality rate of lactic acidosis, as well as the case fatality rate stratified by chronic kidney disease stage, will be calculated. Discussion: The ALIMAR-C2 study will provide useful information about the risk of lactic acidosis in type 2 diabetes mellitus patients with renal impairment using metformin.
Note: Reproducció del document publicat a:
It is part of: BMC Nephrology, 2019, vol. 20, p. 193
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ISSN: 1471-2369
Appears in Collections:Articles publicats en revistes (Patologia i Terapèutica Experimental)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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