Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/163116
Title: Greater default-mode network abnormalities compared to high order visual processing systems in Amnestic Mild Cognitive Impairment. An integrated multi-modal MRI study.
Author: Sala Llonch, Roser
Bosch, Beatriz
Arenaza Urquijo, Eider M.
Rami González, Lorena
Bargalló Alabart, Núria​
Junqué i Plaja, Carme, 1955-
Molinuevo, José Luis
Bartrés Faz, David
Keywords: Amnèsia
Trastorns de la cognició
Còrtex visual
Amnesia
Cognition disorders
Visual cortex
Issue Date: 1-Oct-2010
Publisher: IOS Press
Abstract: We conducted an integrated multi-modal magnetic resonance imaging (MRI) study based on functional MRI (fMRI) data during a complex but cognitively preserved visual task in 15 amnestic mild cognitive impairment (a-MCI) patients and 15 Healthy Elders (HE). Independent Component Analysis of fMRI data identified a functional network containing an Activation Task Related Pattern (ATRP), including regions of the dorsal and ventral visual stream, and a Deactivation Task Related Pattern network (DTRP), with high spatial correspondence with the default-mode network (DMN). Gray matter (GM) volumes of the underlying ATRP and DTRP cortical areas were measured, and probabilistic tractography (based on diffusion MRI) identified fiber pathways within each functional network. For the ATRP network, a-MCI patients exhibited increased fMRI responses in inferior-ventral visual areas, possibly reflecting compensatory activations for more compromised dorsal regions. However, no significant GM or white matter group differences were observed within the ATRP network. For the DTRP/DMN, a-MCI showed deactivation deficits and reduced GM volumes in the posterior cingulate/precuneus, excessive deactivations in the inferior parietal lobe, and less fiber tract integrity in the cingulate bundles. Task performance correlated with DTRP-functionality in the HE group. Besides allowing the identification of functional reorganizations in the cortical network directly processing the task-stimuli, these findings highlight the importance of conducting integrated multi-modal MRI studies in MCI based on spared cognitive domains in order to identify functional abnormalities in critical areas of the DMN and their precise anatomical substrates. These latter findings may reflect early neuroimaging biomarkers in dementia.
Note: Reproducció del document publicat a: https://doi.org/10.3233/JAD-2010-101038
It is part of: Journal of Alzheimer's Disease, 2010, vol. 22, num. 2, p. 523-529
URI: http://hdl.handle.net/2445/163116
Related resource: https://doi.org/10.3233/JAD-2010-101038
ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (Biomedicina)

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