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Title: Cognitive Reserve Proxies Relate to Gray Matter Loss in Cognitively Healthy Elderly with Abnormal Cerebrospinal Fluid Amyloid-β Levels
Author: Arenaza Urquijo, Eider M.
Molinuevo, José Luis
Sala Llonch, Roser
Solé Padullés, Cristina
Balasa, Mircea
Bosch, Beatriz
Olives, Jaume
Antonell, Anna
Lladó Plarrumaní, Albert
Sánchez del Valle Díaz, Raquel
Rami González, Lorena
Bartrés Faz, David
Keywords: Imatges per ressonància magnètica
Envelliment cerebral
Malaltia d'Alzheimer
Líquid cefalorraquidi
Magnetic resonance imaging
Aging brain
Alzheimer's disease
Cerebrospinal fluid
Issue Date: 12-Mar-2013
Publisher: IOS Press
Abstract: Cognitive reserve capacity may increase tolerance of neurodegenerative processes. However, its role regarding amyloid-B (AB 42) deposition in cognitively normal subjects is not well understood. We aimed to investigate the association between areas showing A 42-related structural changes and cognitive reserve proxies in cognitively intact subjects showing normal or abnormal AB 42 cerebrospinal fluid (CSF) concentrations. Thirty-three subjects (aged 55-85) underwent lumbar puncture and high resolution anatomical magnetic resonance imaging analyzed by voxel-based morphometry and cortical thickness procedures. Subjects with abnormal A 42 CSF levels showed significant left hippocampal atrophy and greater cortical thinning in parietal, temporal, and frontal regions (including the supramarginal and the anterior cingulate gyrus) compared to subjects with normalA 42 CSF levels. Using a multivariate general linear model, we investigated the relationship between these areas and cognitive reserve proxies. We found a significant relationship between decreased volume of the left hippocampus or decreased cortical thickness of the right supramarginal gyrus and higher cognitive reserve proxies only in the group with abnormal A 42 CSF levels. Thus, subjects with abnormal A 42 CSF levels (which may be at a higher risk of developing Alzheimer's disease) and with high scores on cognitive reserve proxies may be tolerating a more advanced neurodegenerative process in critical cortical and subcortical regions. The present results emphasize the relevance of evaluating cognitive reserve proxies, as well as the importance of using neuroimaging techniques for early diagnosis in individuals with higher reserve.
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It is part of: Journal of Alzheimer's Disease, 2013, vol. 35, num. 4, p. 715-726
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ISSN: 1387-2877
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Biomedicina)

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