Please use this identifier to cite or link to this item:
Title: Successful outcomes of a new combined solution of hyaluronic acid, chondroitin sulfate and poloxamer 407 for submucosal injection: animal survival study
Author: Córdova, Henry
Cuatrecasas Freixas, Miriam
García-Rodríguez, Ana
Montenegro, Andrea
Melo, Jordana
Rodríguez de Miguel, Cristina
Martínez Palli, Graciela
Garcés-Durán, Rodrigo
Llach Vila, Josep
Fernández Esparrach, Glòria
Keywords: Cirurgia endoscòpica
Histopatologia veterinària
Endoscopic surgery
Veterinary histopathology
Issue Date: 12-Apr-2019
Publisher: Georg Thieme Verlag
Abstract: Background: and study aims Endoscopic resection requires use of submucosal injection. This study was conducted to assess efficacy and impact on early healing of hyaluronic acid combined with chondroitin sulfate and poloxamer 407 (Ziverel) when used as a solution for submucosal injection. Materials: and methods Prospective and comparative study of gastric endoscopic mucosal resection (EMR) with three groups of two Yorkshire pigs. Six submucosal cushions were created in each animal by injecting 2 mL of Ziverel (Group 1) or succinylated gelatin (SG) (Group 2), enabling 12 EMR in each group. Submucosal cushions were created with Ziverel in Group 3, without resection. Electrosurgery unit settings were the same in all cases. EMR defects and injection sites were marked with clips. The animals were sacrificed 7 days later. EMR specimen size and duration of procedure were recorded. EMR specimens and EMR scars and injection sites were evaluated by a blinded pathologist. Results: We successfully performed 24 EMR (15 en-bloc and 9 piecemeal, without differences between groups 1 and 2). Mean EMR specimen dimensions were significantly larger in Group 1 (median 19 mm, range 6 - 40 vs 16.6 mm, range 5‑25; P = 0.019), without changing the electrocautery unit settings. Blinded histopathologist assessment of EMR specimens showed less fibrosis in the submucosa and a trend to fewer cautery artifacts with Ziverel and did not identify any significant differences in early healing of resection sites. Conclusion: The combination of Ziverel enables EMR and does not negatively affect early healing.
Note: Reproducció del document publicat a:
It is part of: Endoscopy International Open, 2019, vol. 7, num. 4, p. E576-E582
Related resource:
ISSN: 2364-3722
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
689936.pdf904.54 kBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons