Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/164191
Title: | Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides |
Author: | González Pizarro, Roberto Carlos Parrotta, Graziella Vera-García, Rodrigo Sánchez-López, E. (Elena) Galindo Camacho, Ruth Milagros Kjeldsen, Frank Badía Palacín, Josefa Baldomà Llavinés, Laura Espina García, Marta García López, María Luisa |
Keywords: | Farmacologia ocular Agents antiinflamatoris Sistemes d'alliberament de medicaments Nanopartícules Uveïtis Polímers Pèptids Ocular pharmacology Antiinflammatory agents Drug delivery systems Nanoparticles Uveitis Polymers Peptides |
Issue Date: | 26-Nov-2019 |
Publisher: | Future Medicine |
Abstract: | Aim: Development of fluorometholone-loaded PEG-PLGA nanoparticles (NPs) functionalized with cellpenetrating peptides for the treatment of ocular inflammatory disorders. Materials & methods: Synthesized polymers and peptides were used for elaboration of functionalized NPs, which were characterized physicochemically. Cytotoxicity and ability to modulate the expression of proinflammatory cytokines were evaluated in vitro using human corneal epithelial cells (HCE-2). NP uptake was assayed in both in vitro and in vivo models. Results: NPs showed physicochemical characteristics suitable for ocular administration without evidence of cytotoxicity. TAT-NPs and G2-NPs were internalized and displayed anti-inflammatory activity in both HCE-2 cells and mouse eye. Conclusion: TAT-NPs and G2-NPs could be considered a novel strategy for the treatment of ocular inflammatory diseases of the anterior and posterior segment. |
Note: | Versió postprint del document publicat a: https://doi.org/10.2217/nnm-2019-0201 |
It is part of: | Nanomedicine, 2019, vol. 14, num. 23, p. 3089-3104 |
URI: | https://hdl.handle.net/2445/164191 |
Related resource: | https://doi.org/10.2217/nnm-2019-0201 |
ISSN: | 1743-5889 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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694447.pdf | 7.48 MB | Adobe PDF | View/Open |
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