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Title: Ocular penetration of fluorometholone-loaded PEG-PLGA nanoparticles functionalized with cell-penetrating peptides
Author: González Pizarro, Roberto Carlos
Parrotta, Graziella
Vera-García, Rodrigo
Sánchez-López, E. (Elena)
Galindo, Ruth
Kjeldsen, Frank
Badía Palacín, Josefa
Baldomà Llavinés, Laura
Espina García, Marta
García López, María Luisa
Keywords: Farmacologia ocular
Agents antiinflamatoris
Sistemes d'alliberament de medicaments
Ocular pharmacology
Antiinflammatory agents
Drug delivery systems
Issue Date: 26-Nov-2019
Publisher: Future Medicine
Abstract: Aim: Development of fluorometholone-loaded PEG-PLGA nanoparticles (NPs) functionalized with cellpenetrating peptides for the treatment of ocular inflammatory disorders. Materials & methods: Synthesized polymers and peptides were used for elaboration of functionalized NPs, which were characterized physicochemically. Cytotoxicity and ability to modulate the expression of proinflammatory cytokines were evaluated in vitro using human corneal epithelial cells (HCE-2). NP uptake was assayed in both in vitro and in vivo models. Results: NPs showed physicochemical characteristics suitable for ocular administration without evidence of cytotoxicity. TAT-NPs and G2-NPs were internalized and displayed anti-inflammatory activity in both HCE-2 cells and mouse eye. Conclusion: TAT-NPs and G2-NPs could be considered a novel strategy for the treatment of ocular inflammatory diseases of the anterior and posterior segment.
Note: Versió postprint del document publicat a:
It is part of: Nanomedicine, 2019, vol. 14, num. 23, p. 3089-3104
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ISSN: 1743-5889
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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