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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/164259
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dc.contributor.authorAmat Tusón, Mercedes-
dc.contributor.authorSubrizi, Fabiana-
dc.contributor.authorElias, Viviane-
dc.contributor.authorLlor Brunés, Núria-
dc.contributor.authorMolins, Elies-
dc.contributor.authorBosch Cartes, Joan-
dc.date.accessioned2020-06-04T08:27:34Z-
dc.date.available2020-06-04T08:27:34Z-
dc.date.issued2012-10-
dc.identifier.issn1434-193X-
dc.identifier.urihttp://hdl.handle.net/2445/164259-
dc.description.abstractStarting from tricyclic lactam 2, which is easily accessible by cyclocondensation of -oxoester 1 with (R)-phenylglycinol, a three-step synthetic route to enantiopure 1-substituted tetrahydroisoquinolines, including 1-alkyl-, 1-aryl-, and 1-benzyl- tetrahydroisoquinoline alkaloids as well as the tricyclic alkaloid (-)-crispine A, has been developed. The key step is a stereoselective -amidoalkylation reaction using the appropriate Grignard reagent.-
dc.format.extent7 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherWiley-VCH-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/ejoc.201200798-
dc.relation.ispartofEuropean Journal of Organic Chemistry, 2012, vol. 2012, num. 28, p. 5491-5497-
dc.relation.urihttps://doi.org/10.1002/ejoc.201200798-
dc.rights(c) Wiley-VCH, 2012-
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)-
dc.subject.classificationSíntesi asimètrica-
dc.subject.classificationAlcaloides-
dc.subject.classificationLactames-
dc.subject.otherAsymmetric synthesis-
dc.subject.otherAlkaloids-
dc.subject.otherLactams-
dc.titleStereoselective synthesis of cis-1,3-dimethyltetrahydroisoquinolines: formal synthesis of naphthylisoquinoline alkaloids-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec615888-
dc.date.updated2020-06-04T08:27:34Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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