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http://hdl.handle.net/2445/164264
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DC Field | Value | Language |
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dc.contributor.author | Fernández-Bañares, Fernando | - |
dc.contributor.author | Clèries Soler, Ramon | - |
dc.contributor.author | Boadas, Jaume | - |
dc.contributor.author | Ribes Puig, Josepa | - |
dc.contributor.author | Oliva, Joan Carles | - |
dc.contributor.author | Alsius, Antoni | - |
dc.contributor.author | Sanz, Xavier | - |
dc.contributor.author | Martínez-Bauer, Eva | - |
dc.contributor.author | Galter, Sara | - |
dc.contributor.author | Pujals, Mar | - |
dc.contributor.author | Pujol, Marta | - |
dc.contributor.author | Del Pozo, Patricia | - |
dc.contributor.author | Campo Fernández de los Rios, Rafael | - |
dc.date.accessioned | 2020-06-04T10:21:30Z | - |
dc.date.available | 2020-06-04T10:21:30Z | - |
dc.date.issued | 2019-07-25 | - |
dc.identifier.issn | 1471-2407 | - |
dc.identifier.uri | http://hdl.handle.net/2445/164264 | - |
dc.description.abstract | Background: Fast-track colonoscopy to detect patients with colorectal cancer based on high-risk symptoms is associated with low sensitivity and specificity. The aim was to derive a predictive score of advanced colonic neoplasia in symptomatic patients in fast-track programs. Methods: All patients referred for fast-track colonoscopy were evaluated. Faecal immunological haemoglobin test (3 samples; positive> 4 μg Hb/g), and a survey to register clinical variables of interest were performed. Colorectal cancer and advanced adenoma were considered as advanced colonic neoplasia. A sample size of 600 and 500 individuals were calculated for each phase 1 and phase 2 of the study, respectively (Phase 1, derivation and Phase 2, validation cohort). A Bayesian logistic regression analysis was used to derive a predictive score. Results: 1495 patients were included. Age (OR, 21), maximum faecal-Hb value (OR, 2.3), and number of positive samples (OR, 28) presented the highest ORs predictive of advanced colonic neoplasia. The additional significant predictive variables adjusted for age and faecal-Hb variables in Phase 1 were previous colonoscopy (last 5 years) and smoking (no, ex/active). With these variables a predictive score of advanced colonic neoplasia was derived. Applied to Phase 2, patients with a Score > 20 had an advanced colonic neoplasia probability of 66% (colorectal cancer, 32%), while those with a Score ≤ 10, a probability of 10% (colorectal cancer, 1%). Prioritizing patients with Score > 10, 49.4% of patients would be referred for fast-track colonoscopy, diagnosing 98.3% of colorectal cancers and 77% of advanced adenomas. Conclusions: A scoring system was derived and validated to prioritize fast-track colonoscopies according to risk, which was efficient, simple, and robust. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s12885-019-5926-4 | - |
dc.relation.ispartof | BMC Cancer, 2019, vol. 19, p. 734 | - |
dc.relation.uri | https://doi.org/10.1186/s12885-019-5926-4 | - |
dc.rights | cc-by (c) Fernández-Bañares, Fernando et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Colonoscòpia | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Tumors | - |
dc.subject.classification | Hemoglobina | - |
dc.subject.other | Colonoscopy | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Tumors | - |
dc.subject.other | Hemoglobin | - |
dc.title | Prediction of advanced colonic neoplasm in symptomatic patients: a scoring system to prioritize colonoscopy (COLONOFIT study). | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 695854 | - |
dc.date.updated | 2020-06-04T10:21:31Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31345180 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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695854.pdf | 861.35 kB | Adobe PDF | View/Open |
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