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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/164357
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dc.contributor.authorAmat Tusón, Mercedes-
dc.contributor.authorElias, Viviane-
dc.contributor.authorLlor Brunés, Núria-
dc.contributor.authorSubrizi, Fabiana-
dc.contributor.authorMolins i Grau, Elies-
dc.contributor.authorBosch Cartes, Joan-
dc.date.accessioned2020-06-04T16:52:40Z-
dc.date.available2020-06-04T16:52:40Z-
dc.date.issued2010-07-12-
dc.identifier.issn1434-193X-
dc.identifier.urihttps://hdl.handle.net/2445/164357-
dc.description.abstractStarting from tricyclic lactam 2 , which is easily accessible by cyclocondensation of δ‐oxoester 1 with (R )‐phenylglycinol, a three‐step synthetic route to enantiopure 1‐substituted tetrahydroisoquinolines, including 1‐alkyl‐, 1‐aryl‐, and 1‐benzyltetrahydroisoquinoline alkaloids, as well as the tricyclic alkaloid (-)‐crispine A, has been developed. The key step is a stereoselective α‐amidoalkylation reaction using the appropriate Grignard reagent.-
dc.format.extent10 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherWiley-VCH-
dc.relation.isformatofVersió postprint del document publicat a: https://doi.org/10.1002/ejoc.201000473-
dc.relation.ispartofEuropean Journal of Organic Chemistry, 2010, vol. 2010, num. 21, p. 4017-4026-
dc.relation.urihttps://doi.org/10.1002/ejoc.201000473-
dc.rights(c) Wiley-VCH, 2010-
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)-
dc.subject.classificationAlcaloides-
dc.subject.classificationLactames-
dc.subject.classificationSíntesi asimètrica-
dc.subject.otherAlkaloids-
dc.subject.otherLactams-
dc.subject.otherAsymmetric synthesis-
dc.titleA general methodology for the enantioselective synthesis of 1-substituted tetrahydroisoquinoline alkaloids-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/acceptedVersion-
dc.identifier.idgrec579166-
dc.date.updated2020-06-04T16:52:40Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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