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https://hdl.handle.net/2445/164358| Title: | A synthetic approach to ervatamine-silicine alkaloids. Enantioselective total synthesis of (-)-episilicine |
| Author: | Amat Tusón, Mercedes Llor Brunés, Núria Checa Castaño, Begoña Molins i Grau, Elies Bosch Cartes, Joan |
| Keywords: | Alcaloides Lactames Síntesi asimètrica Alkaloids Lactams Asymmetric synthesis |
| Issue Date: | 1-Jan-2010 |
| Publisher: | American Chemical Society |
| Abstract: | Starting from an appropriate unsaturated phenylglycinol-derived oxazolopiperidone lactam, the synthesis of (-)-16-episilicine is reported, the key steps being a stereoselective conjugate addition, a stereoselective alkylation, and a ring-closing metathesis reaction. This represents the first enantioselective total synthesis of an alkaloid of the silicine group. |
| Note: | Versió postprint del document publicat a: https://doi.org/10.1021/jo902346j |
| It is part of: | Journal of Organic Chemistry, 2010, vol. 75, num. 1, p. 178-189 |
| URI: | https://hdl.handle.net/2445/164358 |
| Related resource: | https://doi.org/10.1021/jo902346j |
| ISSN: | 0022-3263 |
| Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) Articles publicats en revistes (Institut de Biomedicina (IBUB)) |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 579163.pdf | 454.12 kB | Adobe PDF | View/Open |
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