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http://hdl.handle.net/2445/164367
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DC Field | Value | Language |
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dc.contributor.author | Puig, Pere | - |
dc.contributor.author | Erill, Nadina | - |
dc.contributor.author | Terricabras, Marta | - |
dc.contributor.author | Subirana, Isaac | - |
dc.contributor.author | González-García, Judit | - |
dc.contributor.author | Asensi-Puig, Adrià | - |
dc.contributor.author | Donovan, Michael J. | - |
dc.contributor.author | Mengual Brichs, Lourdes | - |
dc.contributor.author | Agulló-Ortuño, M. Teresa | - |
dc.contributor.author | Olivan Riera, Mireia | - |
dc.contributor.author | Alcaraz Asensio, Antonio | - |
dc.contributor.author | López-Martín, José A. | - |
dc.contributor.author | Torres, Inés de | - |
dc.contributor.author | Rodríguez Peralto, José Luis | - |
dc.contributor.author | Rodríguez-Antolín, Alfredo | - |
dc.contributor.author | Morote, Juan | - |
dc.contributor.author | González-Rumayor, Víctor | - |
dc.date.accessioned | 2020-06-04T21:44:42Z | - |
dc.date.available | 2020-06-04T21:44:42Z | - |
dc.date.issued | 2019-01-30 | - |
dc.identifier.issn | 1756-0500 | - |
dc.identifier.uri | http://hdl.handle.net/2445/164367 | - |
dc.description.abstract | Objectives: To apply a systems pathology-based approach to the quantification of nuclear Active β-catenin and human leukocyte antigen class I, and assess the biomarker involvement in a cohort of prostate tumor patients. Results: The systems pathology approach applied allows a precise quantification of the marker expression in the different cell compartments as well as the determination of the areas that coexpress two markers. Our data shows that the accumulation of β-catenin in the nuclear compartment is significantly decreased in the adjacent normal areas when compared to tumor of the same patients (p < 0.001). In conclusion, the application of this novel multiple immunofluorescence assay demonstrates that the upregulation of Active β-catenin is a relatively common feature of prostate tumor development, and further supports the activation of the Wnt/β-catenin pathway in prostate cancer progression. | - |
dc.format.extent | 5 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s13104-019-4100-z | - |
dc.relation.ispartof | BMC Research Notes, 2019, vol. 12, p. 68 | - |
dc.relation.uri | https://doi.org/10.1186/s13104-019-4100-z | - |
dc.rights | cc-by (c) Puig, Pere et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Càncer de pròstata | - |
dc.subject.classification | Proteïnes | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Prostate cancer | - |
dc.subject.other | Proteins | - |
dc.title | Multiple immunofluorescence assay identifies upregulation of Active β-catenin in prostate cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 698884 | - |
dc.date.updated | 2020-06-04T21:44:43Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 30700322 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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698884.pdf | 753.87 kB | Adobe PDF | View/Open |
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