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Title: Xyloglucan, Hibiscus and Propolis for the prevention of Urinary Tract Infections: results of in vitro studies
Author: Fraile, Benito
Alcover, Javier
Royuela, Mar
Rodríguez, David
Chaves, Concepción
Palacios, Ricardo
Piqué i Clusella, Núria
Keywords: Farmacologia
Cèl·lules epitelials
Infeccions del tracte urinari
Medicaments antibacterians
Escheríchia coli
Epithelial cells
Urinary tract infections
Antibacterial agents
Escherichia coli
Issue Date: 6-Mar-2017
Publisher: Future Medicine
Abstract: Aim: To assess the properties of a medical device containing xyloglucan, propolis and hibiscus to create a bioprotective barrier to avoid the contact of uropathogenic Escherichia coli strains on cell walls in models of intestinal (CacoGoblet) and uroepithelial (RWPE-1) cells (derived from normal human prostate epithelium). Materials & methods: Two uropathogenic E. coli strains (expressing type 1 fimbriae and P fimbriae) were used to assess, by electronic microscopy and ELISA, the barrier properties of the medical device. The antimicrobial activity was assessed in broth dilution assays. Results: The three components (xyloglucan, propolis and hibiscus) did not alter E. coli cell integrity in intestinal and uroepithelial cell models and were devoid of antibacterial activity. The three components avoided bacterial contact in both cell monolayers. Conclusion: The nonpharmacological barrier properties of xyloglucan, propolis and hibiscus confirm the role of the medical device for the management of urinary tract infections.
Note: Versió postprint del document publicat a:
It is part of: Future Microbiology, 2017, vol. 12, p. 721-731
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ISSN: 1746-0913
Appears in Collections:Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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