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http://hdl.handle.net/2445/164730
Title: | Xyloglucan, Hibiscus and Propolis for the prevention of Urinary Tract Infections: results of in vitro studies |
Author: | Fraile, Benito Alcover, Javier Royuela, Mar Rodríguez, David Chaves, Concepción Palacios, Ricardo Piqué i Clusella, Núria |
Keywords: | Farmacologia Microbiologia Fitoteràpia Cèl·lules epitelials Infeccions del tracte urinari Medicaments antibacterians Escheríchia coli Pharmacology Microbiology Phytotherapy Epithelial cells Urinary tract infections Antibacterial agents Escherichia coli |
Issue Date: | 6-Mar-2017 |
Publisher: | Future Medicine |
Abstract: | Aim: To assess the properties of a medical device containing xyloglucan, propolis and hibiscus to create a bioprotective barrier to avoid the contact of uropathogenic Escherichia coli strains on cell walls in models of intestinal (CacoGoblet) and uroepithelial (RWPE-1) cells (derived from normal human prostate epithelium). Materials & methods: Two uropathogenic E. coli strains (expressing type 1 fimbriae and P fimbriae) were used to assess, by electronic microscopy and ELISA, the barrier properties of the medical device. The antimicrobial activity was assessed in broth dilution assays. Results: The three components (xyloglucan, propolis and hibiscus) did not alter E. coli cell integrity in intestinal and uroepithelial cell models and were devoid of antibacterial activity. The three components avoided bacterial contact in both cell monolayers. Conclusion: The nonpharmacological barrier properties of xyloglucan, propolis and hibiscus confirm the role of the medical device for the management of urinary tract infections. |
Note: | Versió postprint del document publicat a: https://doi.org/10.2217/fmb-2017-0015 |
It is part of: | Future Microbiology, 2017, vol. 12, p. 721-731 |
URI: | http://hdl.handle.net/2445/164730 |
Related resource: | https://doi.org/10.2217/fmb-2017-0015 |
ISSN: | 1746-0913 |
Appears in Collections: | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) |
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