Please use this identifier to cite or link to this item:
Title: Correlation of Health-Related Quality of Life in Clinically Stable Outpatients with Schizophrenia.
Author: Domenech, Cristina
Pastore, Adriana
Altamura, A. Carlo
Bernasconi, Corrado
Corral, Ricardo
Elkis, Helio
Evans, Jonathan J.
Malla, Ashok
Margari, Francesco
Krebs, Marie Odile
Nordstroem, Anna Lena
Zink, Mathias
Haro Abad, Josep Maria
Keywords: Esquizofrènia
Qualitat de vida
Quality of life
Issue Date: 20-Dec-2019
Publisher: Dove Medical Press
Abstract: Generic health-related quality of life (HRQoL) scales are increasingly being used to assess the effects of new treatments in schizophrenia. The objective of this study is to better understand the usefulness of generic and condition specific HRQoL scales in schizophrenia by analyzing their correlates. METHODS: Data formed part of the Pattern study, an international observational study among 1379 outpatients with schizophrenia. Patients were evaluated with the Mini International Neuropsychiatric Inventory, the Clinical Global Impression-Schizophrenia (CGI-SCH) Scale and the Positive and Negative Syndrome Scale (PANSS) and reported their HRQoL using the Schizophrenia Quality of Life Scale (SQLS), the Short Form-36 (SF-36), and the EuroQol-5 Dimension (EQ-5D). The two summary values of the SF-36 (the Mental Component Score and the Physical Component Score, SF-36 MCS and SF-36 PCS) were calculated. RESULTS: Higher PANSS positive dimension ratings were associated with worse HRQoL for the SQLS, EQ-5D VAS, SF-36 MCS, and SF-36 PCS. Higher PANSS negative dimension ratings were associated with worse HRQoL for the EQ-5D VAS, SF-36 MCS, and SF-36 PCS, but not for the SQLS or the EQ-5D tariff. PANSS depression ratings were associated with lower HRQoL in all the scales. There was a high correlation between the HRQoL scales. However, in patients with more severe cognitive/disorganized PANSS symptoms, the SQLS score was relatively higher than the EQ-5D tariff and SF-36 PCS scores. CONCLUSION: This study has shown substantial agreement between three HRQoL scales, being either generic or condition specific. This supports the use of generic HRQoL measures in schizophrenia. CLINICALTRIALSGOV IDENTIFIER: NCT01634542 (July 6, 2012, retrospectively registered).
Note: Reproducció del document publicat a:
It is part of: Neuropsychiatric Disease and Treatment, 2019, vol. 15, p. 3475-3486
Related resource:
ISSN: 1176-6328
Appears in Collections:Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
697618.pdf1.35 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons