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Title: A Regenerative Endodontic Approach in Mature Ferret Teeth Using Rodent Preameloblast-conditioned Medium
Author: Bucchi Morales, María Cristina
Gimeno Sandig, Álvaro
Valdivia Gandur, Ivan
Manzanares Céspedes, María Cristina
Anta i Vinyals, Josep Maria de
Keywords: Endodòncia
Polpa dental
Dental pulp
Issue Date: 1-Jul-2019
Publisher: International Institute of Anticancer Research
Abstract: Background: This study evaluated the effectiveness of a regenerative endodontic approach to regenerate the pulp tissue in mature teeth of ferret. The presence of odontoblast-like cells in the newly-formed tissue of teeth treated with or without preameloblast-conditioned medium was evaluated based on morphological criteria. Materials and methods: Twenty-four canines from six ferrets were treated. The pulp was removed, and the apical foramen was enlarged. After inducing the formation of a blood clot, a collagen sponge with or without preameloblast-conditioned medium was placed underneath the cementoenamel junction. The samples were analyzed at the eighth week of follow-up. Results: Vascularized connective tissue was observed in 50% of teeth, without differences between groups. The tissue occupied the apical third of the root canals. Odontoblast-like cells were not observed in any group. Conclusion: Revitalization of mature teeth is possible, at least in the apical third of the root canal. Further experimental research is needed to produce more reliable outcomes.
Note: Reproducció del document publicat a:
It is part of: In Vivo, 2019, vol. 33, num. 4, p. 1143-1150
Related resource:
ISSN: 0258-851X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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