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http://hdl.handle.net/2445/164927
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DC Field | Value | Language |
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dc.contributor.author | Vázquez Valero, Marta | - |
dc.contributor.author | Font Bardia, Ma. Mercedes | - |
dc.contributor.author | Martínez López, Manuel, 1957- | - |
dc.date.accessioned | 2020-06-09T13:32:33Z | - |
dc.date.available | 2020-06-09T13:32:33Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1477-9226 | - |
dc.identifier.uri | http://hdl.handle.net/2445/164927 | - |
dc.description.abstract | Kinetico-mechanistic studies on the substitution reactivity of the [Co{(μ-ET)cyclen}(H2O)2] 3+ complex cation at pH values within the 6.0-7.0 range with biologically significant ligands have been carried out. The substitution processes have been found to occur exclusively on the mono-hydroxobridged [(Co{(μ-ET)cyclen}(H2O))2(μ-OH)]5+ species formed after equilibration of the cobalt complex in the relevant medium. The studies conducted on the substitution of the aqua/hydroxo ligands of this dinuclear species are indicative of a dominant role of outer-sphere complexation, involving hydrogen-bonding interactions. The values of the outer-sphere complex formation equilibrium constant are in line with the intervention of both the exiting aqua ligands and the NH groups at the encapsulating {(μ-ET)cyclen} ligand. These complexes result in the preferential formation of O- or N-bonded nucleotides depending on the structure of the base moiety of the ligand. Even the entry of the different donor bonded nucleotides is hampered by the hydrogen-bonding interaction with the dangling moiety of an already coordinated ligand. In general the overall substitution processes occur at a faster rate than those published for the fully alkylated encapsulating {(Me)2(μ-ET)cyclen} ligand derivative, as expected for the still available base-catalysing NH groups in the {(μ-ET)cyclen} ligand. | - |
dc.format.extent | 30 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1039/C5DT01816A | - |
dc.relation.ispartof | Dalton Transactions, 2015, vol. 44, num. 42, p. 18643-18655 | - |
dc.relation.uri | https://doi.org/10.1039/C5DT01816A | - |
dc.rights | (c) Vázquez Valero, Marta et al., 2015 | - |
dc.source | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) | - |
dc.subject.classification | Cinètica química | - |
dc.subject.classification | Química bioinorgànica | - |
dc.subject.classification | Reaccions de substitució | - |
dc.subject.other | Chemical kinetics | - |
dc.subject.other | Bioinorganic chemistry | - |
dc.subject.other | Substitution reactions | - |
dc.title | Kinetico-mechanistic studies on substitution reactions on cross-bridged cyclen CoIII complexes with nucleosides and nucleotides | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 654792 | - |
dc.date.updated | 2020-06-09T13:32:34Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) |
Files in This Item:
File | Description | Size | Format | |
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654792.pdf | 1.7 MB | Adobe PDF | View/Open |
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