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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/165079
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dc.contributor.authorPedrola, Marina-
dc.contributor.authorJorba, Marta-
dc.contributor.authorJardas, Eda-
dc.contributor.authorJardi, Ferran-
dc.contributor.authorGhashghaei, Ouldouz-
dc.contributor.authorViñas, Miquel-
dc.contributor.authorLavilla Grífols, Rodolfo-
dc.date.accessioned2020-06-10T15:05:35Z-
dc.date.available2020-06-10T15:05:35Z-
dc.date.issued2019-07-04-
dc.identifier.issn2296-2646-
dc.identifier.urihttp://hdl.handle.net/2445/165079-
dc.description.abstractNovel antibiotic compounds have been prepared through a selective multicomponent reaction upon the known drug Trimethoprim. The Groebke-Blackburn-Bienaymé reaction involving this α-aminoazine, with a range of aldehydes and isocyanides afforded the desired adducts in one-step. The analogs display meaningful structural features of the initial drug together with relevant modifications at several points, keeping antibiotic potency and showing satisfactory antimicrobial profile (good activity levels and reduced growth rates), especially against methicillin-resistant Staphylococcus aureus. The new products may open new possibilities to fight bacterial infections.-
dc.format.extent9 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherFrontiers Media-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3389/fchem.2019.00475-
dc.relation.ispartofFrontiers in Chemistry, 2019, vol. 7, p. 475-
dc.relation.urihttps://doi.org/10.3389/fchem.2019.00475-
dc.rightscc-by (c) Pedrola, Marina et al., 2019-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)-
dc.subject.classificationAntibiòtics-
dc.subject.classificationMedicaments-
dc.subject.classificationBacteris-
dc.subject.classificationIsonitrils-
dc.subject.otherAntibiotics-
dc.subject.otherDrugs-
dc.subject.otherBacteria-
dc.subject.otherIsocyanides-
dc.titleMulticomponent Reactions upon the Known Drug Trimethoprim as a Source of Novel Antimicrobial Agents-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec691038-
dc.date.updated2020-06-10T15:05:35Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid31334221-
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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