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DC Field | Value | Language |
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dc.contributor.author | Millán López, Olga | - |
dc.contributor.author | Ruiz, P. | - |
dc.contributor.author | Orts, Lara | - |
dc.contributor.author | Ferré Aparicio, Paula | - |
dc.contributor.author | Crespo, Gonzalo | - |
dc.contributor.author | Santana, Miguel | - |
dc.contributor.author | Fortuna, Virginia | - |
dc.contributor.author | Quintairos Domenech, Luis | - |
dc.contributor.author | Navasa, Miquel | - |
dc.contributor.author | Brunet i Serra, Mercè | - |
dc.date.accessioned | 2020-06-10T15:52:27Z | - |
dc.date.available | 2020-06-10T15:52:27Z | - |
dc.date.issued | 2019-04-24 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/2445/165100 | - |
dc.description.abstract | Background and Aims: News strategies for the accurate assessment of the state of immunosuppression (IS) in liver transplant recipients are needed to prevent rejection and minimize drug-related side effects. miRNAs can potentially be used as diagnostic or prognostic biomarkers in transplant patients. This study evaluated the capacity of a plasmatic miRNA panel (miR-155-5p, miR-122-5p, miR-181a-5p, and miR148-3p) as an early non-invasive prognostic and diagnostic biomarker for T cell-mediated acute rejection (TCMAR) and subclinical rejection (SCR) in adult liver recipients. Methods: A total of 145 liver recipients were included. All patients received a calcineurin inhibitor with or without mycophenolate mofetil and methylprednisolone. Plasmatic miRNA expression was assessed by qPCR before and at different time-points after liver transplantation. Results: Seventeen patients experienced TCMAR, and eight were diagnosed with SCR during the protocol biopsy at the 3rd month post-transplantation. Pre-transplantation, miR-155-5p expression was significantly higher in TCMAR patients and in SCR patients than in non-rejectors, and miR-181a-5p expression was also significantly higher in SCR patients than in non-rejectors. Post-transplantation, before transaminase-level modification, significantly increased miR-181a-5p, miR-155-5p, and miR-122-5p expression was observed in TCMAR and SCR patients. Binary logistic regression analyses showed, post-transplantation, that TCMAR risk was better predicted by individual expression of miR-181a-5p (LOGIT = -6.35 + 3.87*miR-181a-5p), and SCR risk was better predicted by the combination of miR-181a-5p and miR-155-5p expression (LOGIT = -5.18 + 2.27*miR-181a-5p+1.74*miR-155-5p). Conclusions: Pre-transplantation plasmatic miR-155-5p expression may be useful for stratifying low-immunologic-risk patients, and post-transplantation miR-181a-5p and miR-155-5p may be candidates for inclusion in early, non-invasive prognostic biomarker panels to prevent TCMAR or SCR and better identify patient candidates for IS minimization. Large prospective randomized multicenter trials are needed to refine the cut-off values and algorithms and validate the clinical usefulness of these biomarkers. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2019 | - |
dc.relation.ispartof | Frontiers in Immunology, 2019, vol. 10, p. 873 | - |
dc.relation.uri | https://doi.org/10.3389/fimmu.2019 | - |
dc.rights | cc-by (c) Millán López, Olga et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Trasplantament hepàtic | - |
dc.subject.classification | Immunosupressió | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Hepatic transplantation | - |
dc.subject.other | Immunosuppression | - |
dc.title | Monitoring of miR-181a-5p and miR-155-5p Plasmatic Expression as Prognostic Biomarkers for Acute and Subclinical Rejection in de novo Adult Liver Transplant Recipients. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 692568 | - |
dc.date.updated | 2020-06-10T15:52:27Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31068943 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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692568.pdf | 2.34 MB | Adobe PDF | View/Open |
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