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http://hdl.handle.net/2445/165170
Title: | Using an overlapping time interval strategy to study diagnostic instability in mild cognitive impairment subtypes. |
Author: | Facal, David Guàrdia-Olmos, Joan, 1958- Pereiro, Arturo X. Lojo-Seoane, Cristina Peró, Maribel Juncos-Rabadán, Onésimo |
Keywords: | Neurociència cognitiva Estadística bayesiana Demència Cognitive neuroscience Bayesian statistical decision Dementia |
Issue Date: | 19-Sep-2019 |
Publisher: | MDPI |
Abstract: | (1) Background: Mild cognitive impairment (MCI) is a diagnostic label in which stability is typically low. The aim of this study was to examine temporal changes in the diagnosis of MCI subtypes by using an overlapping-time strategy; (2) Methods: The study included 435 participants aged over 50 years with subjective cognitive complaints and who completed at least one follow-up evaluation. The probability of transition was estimated using Bayesian odds ratios; (3) Results: Within the different time intervals, the controls with subjective cognitive complaints represented the largest proportion of participants, followed by sda-MCI at baseline and in the first five intervals of the follow-up, but not in the last eight intervals. The odds ratios indicated higher odds of conversion to dementia in sda-MCI and mda-MCI groups relative to na-MCI (e.g., interval 9-15 months-sda-MCI OR = 9 and mda-MCI OR = 3.36; interval 27-33-sda-MCI OR = 16 and mda-MCI = 5.06; interval 42-48-sda-MCI OR = 8.16 and mda-MCI = 3.45; interval 45-51-sda-MCI OR = 3.31 and mda-MCI = 1); (4) Conclusions: Notable patterns of instability consistent with the current literature were observed. The limitations of a prospective approach in the study of MCI transitions are discussed. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/brainsci9090242 |
It is part of: | Brain Sciences, 2019, vol. 9, num. 9, p. 242 |
URI: | http://hdl.handle.net/2445/165170 |
Related resource: | https://doi.org/10.3390/brainsci9090242 |
ISSN: | 2076-3425 |
Appears in Collections: | Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa) |
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