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Title: A New Family of Doubly Cyclopalladated Diimines. A Remarkable Effect of the Linker between the Metalated Units on Their Cytotoxicity
Author: Albert Mach, Joan
Bosque Pueyo, Ramón
Cadena, M.
D'Andrea Rodríguez-Vida, Lucía
Granell Sanvicente, Jaime Ramón
González, A.
Quirante Serrano, Josefina
Calvis, Carme
Messeguer i Peypoch, Ramon
Badía Palacín, Josefa
Baldomà Llavinés, Laura
Calvet Pallàs, Maria Teresa
Font Bardia, Ma. Mercedes
Keywords: Platí
Pal·ladi (Element químic)
Toxicitat dels medicaments
Drug toxicity
Issue Date: 2014
Publisher: American Chemical Society
Abstract: The cyclopalladation of a series of symmetric diimines with the formula (RC6H4CHNZ)2, where Z = CH2 or (CH2)2OCH2 and R = p-Cl, p-OMe, p-NO2, and o-Cl, is described. Optimal conditions to obtain the dimetalated compounds were found to be palladium(II) acetate, in toluene, at 60 °C and with a reaction time of 2−4 h. The reactivity of the dimetalated compounds with monodentate, bidentate, and bis(monodentate) Lewis bases was also studied. The cytotoxic activity of some selected compounds was evaluated against a panel of adenocarcinoma cell lines (colon HCT116 and breast MCF7 and MDA-MB231). Compounds containing the fragment NCH2CH2OCH2CH2OCH2CH2N exhibited a remarkable cytotoxic activity in the three cancer cells assayed, but complexes containing the NCH2CH2N fragment showed no activity. It seems that the length and flexibility of the central saturated chain in the imine molecule, as well as its lipophilicity and hydrophilicity, explain the different cytotoxicity of the two series of coordination compounds here reported.
Note: Versió postprint del document publicat a:
It is part of: Organometallics, 2014, vol. 33, num. 11, p. 2862-2873
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ISSN: 0276-7333
Appears in Collections:Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

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