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Title: | A New Family of Doubly Cyclopalladated Diimines. A Remarkable Effect of the Linker between the Metalated Units on Their Cytotoxicity |
Author: | Albert Mach, Joan Bosque Pueyo, Ramón Cadena, M. D'Andrea Rodríguez-Vida, Lucía Granell Sanvicente, Jaime Ramón González, A. Quirante Serrano, Josefina Calvis, Carme Messeguer i Peypoch, Ramon Badía Palacín, Josefa Baldomà Llavinés, Laura Calvet Pallàs, Maria Teresa Font Bardia, Ma. Mercedes |
Keywords: | Platí Pal·ladi (Element químic) Lligands Genètica Toxicitat dels medicaments Platinum Palladium Ligands Genetics Drug toxicity |
Issue Date: | 2014 |
Publisher: | American Chemical Society |
Abstract: | The cyclopalladation of a series of symmetric diimines with the formula (RC6H4CHNZ)2, where Z = CH2 or (CH2)2OCH2 and R = p-Cl, p-OMe, p-NO2, and o-Cl, is described. Optimal conditions to obtain the dimetalated compounds were found to be palladium(II) acetate, in toluene, at 60 °C and with a reaction time of 2−4 h. The reactivity of the dimetalated compounds with monodentate, bidentate, and bis(monodentate) Lewis bases was also studied. The cytotoxic activity of some selected compounds was evaluated against a panel of adenocarcinoma cell lines (colon HCT116 and breast MCF7 and MDA-MB231). Compounds containing the fragment NCH2CH2OCH2CH2OCH2CH2N exhibited a remarkable cytotoxic activity in the three cancer cells assayed, but complexes containing the NCH2CH2N fragment showed no activity. It seems that the length and flexibility of the central saturated chain in the imine molecule, as well as its lipophilicity and hydrophilicity, explain the different cytotoxicity of the two series of coordination compounds here reported. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1021/om500382f |
It is part of: | Organometallics, 2014, vol. 33, num. 11, p. 2862-2873 |
URI: | http://hdl.handle.net/2445/165437 |
Related resource: | https://doi.org/10.1021/om500382f |
ISSN: | 0276-7333 |
Appears in Collections: | Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada) |
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