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http://hdl.handle.net/2445/165670
Title: | Rectal Aberrant Crypt Foci in Humans Are Not Surrogate Markers for Colorectal Cancer Risk |
Author: | Quintanilla Leo, Isabel López-Cerón Pinilla, María Jimeno, Mireya Cuatrecasas Freixas, Miriam Zabalza, Michel Moreira, Leticia Alonso-Espinaco, Virginia Rodríguez de Miguel, Cristina Muñoz, Jenifer Castellví Bel, Sergi Llach Vila, Josep Castells Garangou, Antoni Balaguer Prunés, Francesc Camps, Jordi Pellisé Urquiza, Maria |
Keywords: | Càncer colorectal Etiologia Endoscòpia Colorectal cancer Etiology Endoscopy |
Issue Date: | 15-May-2019 |
Publisher: | Wolters Kluwer Health |
Abstract: | NTRODUCTION: Over the past 20 years, aberrant crypt foci (ACF) have emerged as potential precursors and biomarkers for colorectal cancer (CRC). However, data regarding their molecular pathogenesis, as well as their endoscopic and histological identification, remain inconsistent. METHODS: A wide cohort of ACF from 100 control subjects and 100 case patients, including patients with adenoma and CRC, were characterized for endoscopic, morphologic, and molecular features. RESULTS: We observed that among all the endoscopic features evaluated, only the number of large ACF correlated with CRC risk (P = 0.003), whereas the histological classification, as assessed by 2 different pathologists, was inconsistent and did not differ between control and case patients. Moreover, only a few APC and BRAF mutations and no microsatellite instability were detected in our samples. KRAS mutations were detected in 16.3% of ACF samples, which also exhibited increased MGMT hypermethylation. However, none of those events were found to be predictive of CRC risk. DISCUSSION: Although ACF might be preneoplastic lesions of the colon, they are not suitable biomarkers for assessing CRC progression. |
Note: | Reproducció del document publicat a: https://doi.org/10.14309/ctg.0000000000000047 |
It is part of: | Clinical and Translational Gastroenterology, 2019, vol. 10, num. 6, p. 00047 |
URI: | http://hdl.handle.net/2445/165670 |
Related resource: | https://doi.org/10.14309/ctg.0000000000000047 |
ISSN: | 2155-384X |
Appears in Collections: | Articles publicats en revistes (Fonaments Clínics) |
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