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http://hdl.handle.net/2445/165996
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DC Field | Value | Language |
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dc.contributor.author | Oriol, Isabel | - |
dc.contributor.author | Fernández Sabé, Núria | - |
dc.contributor.author | Càmara, J. | - |
dc.contributor.author | Berbel, Dàmaris | - |
dc.contributor.author | Ballesteros, M. A. | - |
dc.contributor.author | Escudero, R. | - |
dc.contributor.author | López Medrano, Francisco | - |
dc.contributor.author | Linares, Laura | - |
dc.contributor.author | Len, Óscar | - |
dc.contributor.author | Silva, J. T. | - |
dc.contributor.author | Oliver, E. | - |
dc.contributor.author | Soldevila, L. | - |
dc.contributor.author | Pérez Recio, S. | - |
dc.contributor.author | Guillem, LL. | - |
dc.contributor.author | Camprubí, Daniel | - |
dc.contributor.author | Lladó Garriga, Laura | - |
dc.contributor.author | Manonelles, Anna | - |
dc.contributor.author | González-Costello, José | - |
dc.contributor.author | Domínguez Luzón, Ma. Ángeles (María Ángeles) | - |
dc.contributor.author | Fariñas, M. C. | - |
dc.contributor.author | Lavid, N. | - |
dc.contributor.author | González Rico, C. | - |
dc.contributor.author | Garcia Cuello, L. | - |
dc.contributor.author | Arnaiz de Las Revillas, F. | - |
dc.contributor.author | Fortun, J. | - |
dc.contributor.author | Aguado, José María | - |
dc.contributor.author | Jimenez Romero, C. | - |
dc.contributor.author | Bodro, Marta | - |
dc.contributor.author | Almela, M. (Manel) | - |
dc.contributor.author | Paredes, D. (David) | - |
dc.contributor.author | Moreno, A. | - |
dc.contributor.author | Pérez Cameo, C. | - |
dc.contributor.author | Muñoz Sanz, A. | - |
dc.contributor.author | Blanco Fernández, G. | - |
dc.contributor.author | Cabo González, J. A. | - |
dc.contributor.author | García López, J. L. | - |
dc.contributor.author | Nuño, E. | - |
dc.contributor.author | Carratalà, Jordi | - |
dc.date.accessioned | 2020-06-17T10:28:09Z | - |
dc.date.available | 2020-06-17T10:28:09Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2328-8957 | - |
dc.identifier.uri | http://hdl.handle.net/2445/165996 | - |
dc.description.abstract | Background: We analyzed the prevalence, etiology, and risk factors of culture-positive preservation fluid and their impact on the management of solid organ transplant recipients. Methods: From July 2015 to March 2017, 622 episodes of adult solid organ transplants at 7 university hospitals in Spain were prospectively included in the study. Results: The prevalence of culture-positive preservation fluid was 62.5% (389/622). Nevertheless, in only 25.2% (98/389) of the cases were the isolates considered "high risk" for pathogenicity. After applying a multivariate regression analysis, advanced donor age was the main associated factor for having culture-positive preservation fluid for high-risk microorganisms. Preemptive antibiotic therapy was given to 19.8% (77/389) of the cases. The incidence rate of preservation fluid-related infection was 1.3% (5 recipients); none of these patients had received preemptive therapy. Solid organ transplant (SOT) recipients with high-risk culture-positive preservation fluid receiving preemptive antibiotic therapy presented both a lower cumulative incidence of infection and a lower rate of acute rejection and graft loss compared with those who did not have high-risk culture-positive preservation fluid. After adjusting for age, sex, type of transplant, and prior graft rejection, preemptive antibiotic therapy remained a significant protective factor for 90-day infection. Conclusions: The routine culture of preservation fluid may be considered a tool that provides information about the contamination of the transplanted organ. Preemptive therapy for SOT recipients with high-risk culture-positive preservation fluid may be useful to avoid preservation fluid-related infections and improve the outcomes of infection, graft loss, and graft rejection in transplant patients. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1093/ofid/ofz180 | - |
dc.relation.ispartof | Open Forum Infectious Diseases, 2019, vol. 26, num. 6, p. 180 | - |
dc.relation.uri | https://doi.org/10.1093/ofid/ofz180 | - |
dc.rights | cc-by-nc-nd (c) Oriol, I. et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Trasplantament d'òrgans | - |
dc.subject.classification | Antibiòtics | - |
dc.subject.classification | Anàlisi de regressió | - |
dc.subject.classification | Infeccions | - |
dc.subject.other | Transplantation of organs | - |
dc.subject.other | Antibiotics | - |
dc.subject.other | Regression analysis | - |
dc.subject.other | Infections | - |
dc.title | The Impact of Culturing the Organ Preservation Fluid on Solid Organ Transplantation: A Prospective Multicenter Cohort Study. Open Forum Infect Dis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 695234 | - |
dc.date.updated | 2020-06-17T10:28:09Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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695234.pdf | 342.17 kB | Adobe PDF | View/Open |
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