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http://hdl.handle.net/2445/166524
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DC Field | Value | Language |
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dc.contributor.author | Barbosa, Thallysson Carvalho | - |
dc.contributor.author | Dias Nascimento, Lívia Éven | - |
dc.contributor.author | Bani, Cristiane | - |
dc.contributor.author | Almeida, Taline | - |
dc.contributor.author | Nery, Marcelo | - |
dc.contributor.author | Santos, Rafael Silva | - |
dc.contributor.author | de Oliveira Menezes, Luana Renyelle | - |
dc.contributor.author | Zielinska, Aleksandra | - |
dc.contributor.author | Fernandes, Ana Rita | - |
dc.contributor.author | Cordeiro Cardoso, Juliana | - |
dc.contributor.author | Jäguer, Alessandro | - |
dc.contributor.author | Jäguer, Eliezer | - |
dc.contributor.author | Sánchez-López, E. (Elena) | - |
dc.contributor.author | Nalone, Luciana | - |
dc.contributor.author | Barbosa Souto, Eliana | - |
dc.contributor.author | Severino, Patrícia | - |
dc.date.accessioned | 2020-06-23T10:08:45Z | - |
dc.date.available | 2020-06-23T10:08:45Z | - |
dc.date.issued | 2019-09-22 | - |
dc.identifier.issn | 2305-6304 | - |
dc.identifier.uri | http://hdl.handle.net/2445/166524 | - |
dc.description.abstract | The objective of this work was to characterize the toxicological profile of a newly developed sunscreen formulation based on polymeric nanocapsules (NCs) loading benzophenone-3 (BZP3). NCs composed of poly(ε-caprolactone) carrot oil and Pluronic® F68 were produced by emulsification-diffusion method. Their mean particle size (Z-Ave) ranged from 280 to 420 nm, polydispersity index (PDI) was below 0.37, while zeta potential (ZP) reached about |+11 mV|. No cytotoxic effects were observed in L929 fibroblast cell line for the blank (i.e., non-loaded) NCs and BZP3-loaded NCs (BZP3-NCs). The semi-solid sunscreen formulation was stable over time (centrifugation testing) and exhibited non-Newtonian pseudoplastic behavior, which is typical of products for topical application onto the skin. The sun protection factor (SPF) value reached 8.84, when incorporating BZP3-NCs (SPF of 8.64) into the semi-solid formulation. A synergistic effect was also observed when combining the formulation ingredients of nanocapsules, i.e., SPF of carrot oil was 6.82, blank NCs was 6.84, and BZP3-loaded NCs was 8.64. From the hen's egg-chorioallantoic membrane test (HET-CAM) test, the non-irritation profile of the developed formulations could also be confirmed. The obtained results show a promising use of poly(ε-caprolactone) nanocapsules to be loaded with lipophilic sunscreens as benzophenone-3 | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/toxics7040051 | - |
dc.relation.ispartof | Toxics, 2019, vol. 7, num. 4, p. 51 | - |
dc.relation.uri | https://doi.org/10.3390/toxics7040051 | - |
dc.rights | cc-by (c) Barbosa, Thallysson Carvalho et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) | - |
dc.subject.classification | Toxicologia experimental | - |
dc.subject.classification | Farmacocinètica | - |
dc.subject.classification | Farmacologia | - |
dc.subject.classification | Protectors solars | - |
dc.subject.classification | Emulsions | - |
dc.subject.other | Experimental toxicology | - |
dc.subject.other | Pharmacokinetics | - |
dc.subject.other | Pharmacology | - |
dc.subject.other | Sunscreens (Cosmetics) | - |
dc.subject.other | Emulsions | - |
dc.title | Development, cytotoxicity and eye irritation profile of a new sunscreen formulation based on benzophenone-3-poly(ε-caprolactone) nanocapsules. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 701306 | - |
dc.date.updated | 2020-06-23T10:08:45Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 31546707 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB)) Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
Files in This Item:
File | Description | Size | Format | |
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701306.pdf | 2.44 MB | Adobe PDF | View/Open |
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