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DC Field | Value | Language |
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dc.contributor.author | Batista, Everton S. | - |
dc.contributor.author | Oliveira, Pedro D. | - |
dc.contributor.author | Primo, Janeusa | - |
dc.contributor.author | Varandas, Cinthya Maria Neves | - |
dc.contributor.author | Nunes, Ana Paula | - |
dc.contributor.author | Bittencourt, Achiléa L. | - |
dc.contributor.author | Farré, Lourdes | - |
dc.date.accessioned | 2020-06-29T12:36:26Z | - |
dc.date.available | 2020-06-29T12:36:26Z | - |
dc.date.issued | 2019-12-18 | - |
dc.identifier.uri | http://hdl.handle.net/2445/166905 | - |
dc.description.abstract | Introduction Infective dermatitis associated with HTLV-1 (IDH) is a recurrent eczema which affects children vertically infected with HTLV-1. In Bahia, Brazil, we recently reported that 47% of IDH patients also develop juvenile HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive disabling disorder which is typically reported in adult HTLV-1 carriers. IDH may also predispose to adult T-cell leukemia/lymphoma, a neoplasm associated with HTLV-1. The factors relating to the development of HTLV-1-associated juvenile diseases have not yet been defined. HTLV-1 proviral load (PVL) is one of the main parameters related to the development of HTLV-1 associated diseases in adults. In the current study, we investigated the role of PVL in IDH and juvenile HAM/TSP. Methodology/Principal findings This is a cohort study that included fifty-nine HTLV-1 infected children and adolescents, comprising 16 asymptomatic carriers, 18 IDH patients, 20 patients with IDH and HAM/TSP (IDH/HAM/TSP) and five with HAM/TSP. These patients were followed-up for up to 14 years (median of 8 years). We found that PVL in IDH and IDH/HAM/TSP patients were similarly higher than PVL in juvenile asymptomatic carriers (p<0.0001). In those IDH patients who developed HAM/TSP during follow-up, PVL levels did not vary significantly. HAM/TSP development did not occur in those IDH patients who presented high levels of PVL. IDH remission was associated with an increase of PVL. Inter-individual differences in PVL were observed within all groups. However, intra-individual PVL did not fluctuate significantly during follow-up. Conclusions/Significance High PVL in IDH patients was not necessary indicative of progression to HAM/TSP. PVL did not decrease after IDH remission. The maintenance of high PVL after remission could favor early development of ATL. Therefore, IDH patients would have to be followed-up even after remission of IDH and for a long period of time. | ca |
dc.description.sponsorship | This work was supported by the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB, www.fapesb.ba.gov.br) [Grant number RED0028/2012 to L.F.], Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, www.cnpq.br)[Grant number 409985/ 2016-3 to A.L.B.]. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska Marie Curie grant (https://ec.europa.eu) [agreement number 799850 to L.F.] The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | ca |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pntd.0007705 | - |
dc.relation.ispartof | PLoS Neglected Tropical Diseases, 2019, vol. 13, num. 12, p. e0007705. | - |
dc.rights | cc-by (c) Batista et al., 2019 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Dermatitis | - |
dc.subject.classification | Medicina tropical | - |
dc.subject.other | Dermatitis | - |
dc.subject.other | Tropical medicine | - |
dc.title | HTLV-1 proviral load in infective dermatitis associated with HTLV-1 does not increase after the development of HTLV-1-associated myelopathy/tropical spastic paraparesis and does not decrease after IDH remission | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.doi | https://doi.org/10.1371/journal.pntd.0007705 | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/799850/EU//PORTAL | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca |
dc.identifier.pmid | 31851683 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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pntd.0007705.pdf | 1.07 MB | Adobe PDF | View/Open |
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