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Title: Clinical implications of estimating glomerular filtration rate with three different equations among older people: preliminary results of the project 'Screening for Chronic Kidney Disease Among Older People Across Europe (SCOPE)'
Author: Corsonello, Andrea
Roller-Wirnsberger, Regina
Wirnsberger, Gerhard
Ärnlöv, Johan
Carlsson, Axel C.
Tap, Lisanne
Mattace-Raso, Francesco
Formiga Pérez, Francesc
Moreno González, Rafael
Weingart, Christian
Sieber, Cornel
Kostka, Tomasz
Guligowska, Agnieszka
Gil, Pedro
Lainez Martinez, Sara
Artzi-Medvedik, Rada
Melzer, Itshak
Lattanzio, Fabrizia
SCOPE investigators
Keywords: Malalties del ronyó
Persones grans
Kidney diseases
Older people
Issue Date: 21-Jan-2020
Publisher: MDPI
Abstract: We aimed at investigating to what extent CKD may be staged interchangeably by three different eGFR equations in older people, and evaluating the source of discrepancies among equations in a population of 2257 patients older than 75 years enrolled in a multicenter observational study. eGFR was calculated by CKD-EPI, BIS and FAS equations. Statistical analysis was carried out by Bland-Altman analysis. κ statistic was used to quantify the agreement between equations in classifying CKD stages. The impact of selected variables on the difference among equations was graphically explored. The average difference between BIS and FAS was -0.24 (95% limits of agreement (95%LA = -4.64-4.14) mL/min/1.73 m2. The difference between CKD-EPI and BIS and between CKD-EPI and FAS was 8.97 (95%LA = -2.90-20.84) and 8.72 (95%LA = -2.11-19.56) mL/min/1.73 m2, respectively. As regards CKD stage classification, κ value was 0.47 for both CKD-EPI vs. FAS and CKD-EPI vs. BIS, while BIS and FAS had similar classificatory properties (κ = 0.90). Muscle mass was found related to the difference between CKD-EPI and BIS (R2 = 0.11) or FAS (R2 = 0.14), but not to the difference between BIS and FAS. In conclusion, CKD-EPI and BIS/FAS equations are not interchangeable to assess eGFR among older people. Muscle mass may represent a relevant source of discrepancy among eGFR equations.
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It is part of: Journal of Clinical Medicine, 2020, vol. 9, num. 2, p. 294
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ISSN: 2077-0383
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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