Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/167300
Title: | Facilitated anion transport induces hyperpolarization of the cell membrane that triggers differentiation and cell death in cancer stem cells |
Author: | Soto Cerrato, Vanessa Manuel-Manresa, Pilar Hernando, Elsa Calabuig-Fariñas, Silvia Martínez-Romero, Alicia Fernández Dueñas, Víctor Sahlholm, Kristoffer Knöpfel, Thomas García Valverde, María Rodilla Martín, Ananda Marina Jantus Lewintre, Eloisa Farràs, Rosa Ciruela Alférez, Francisco Pérez Tomás, Ricardo E. Quesada, Roberto |
Keywords: | Apoptosi Fisiologia Cèl·lules mare Patologia Apoptosis Physiology Stem cells Pathology |
Issue Date: | 23-Dec-2015 |
Publisher: | American Chemical Society |
Abstract: | Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores is still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the effect induced by these compounds at the cellular level. We show how active anionophores, capable of facilitating the transmembrane transport of chloride and bicarbonate in model phospholipid liposomes, induce acidification of the cytosol and hyperpolarization of plasma cell membranes. We demonstrate how this combined effect can be used against cancer stem cells (CSCs). Hyperpolarization of cell membrane induces cell differentiation and loss of stemness of CSCs leading to effective elimination of this cancer cell subpopulation. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1021/jacs.5b09970 |
It is part of: | Journal of the American Chemical Society, 2015, vol. 137, num. 50, p. 15892-15898 |
URI: | http://hdl.handle.net/2445/167300 |
Related resource: | https://doi.org/10.1021/jacs.5b09970 |
ISSN: | 0002-7863 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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