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Title: Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres
Author: Kühne, Britta A.
Puig i Miquel, Teresa
Ruiz-Martínez, Santiago
Crous-Masó, Joan
Planas, Marta
Feliu, Lidia
Cano Fernández, Amanda
García, Maria Luisa
Fritsche, Ellen
Llobet Mallafré, Joan M. (Joan Maria)
Gómez Catalán, Jesús
Barenys Espadaler, Marta
Keywords: Suplements nutritius
Dietary supplements
Issue Date: 1-Jan-2019
Publisher: Elsevier Ltd
Abstract: Epigallocatechin gallate (EGCG), the main catechin of green tea, is described to have potential health benefits in several fields like oncology, neurology or cardiology. Currently, it is also under pre-clinical investigation as a potential therapeutic or preventive treatment during pregnancy against developmental adverse effects induced by toxic substances. However, the safety of EGCG during pregnancy is unclear due to its proven adverse effects on neural progenitor cells' (NPCs) migration. As lately several strategies have arisen to generate new therapeutic agents derived from EGCG, we have used the rat 'Neurosphere Assay' to characterize and compare the effects of EGCG structurally related compounds and EGCG PEGylated PLGA nanoparticles on a neurodevelopmental key event: NPCs migration. Compounds structurally-related to EGCG induce the same pattern of NPCs migration alterations (decreased migration distance, decreased formation of migration corona, chaotic orientation of cellular processes and decreased migration of neurons at higher concentrations). The potency of the compounds does not depend on the number of galloyl groups, and small structure variations can imply large potency differences. Due to their lower toxicity observed in vitro in NPCs, 4,4′-bis[(3,4,5-trihydroxybenzoyl)oxy]-1,1′-biphenyl and EGCG PEGylated PLGA nanoparticles are suggested as potential future therapeutic or preventive alternatives to EGCG during prenatal period​
Note: Versió postprint del document publicat a:
It is part of: Food and Chemical Toxicology, 2019, vol. 123, p. 195-204
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ISSN: 0278-6915
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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