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http://hdl.handle.net/2445/167709
Title: | Chronic liquid fructose, but not glucose, supplementation selectively induces visceral adipose tissue leptin resistance and hypeertrophy in female Sprague-Dawley rats |
Author: | Sangüesa Puigventós, Gemma Roglans i Ribas, Núria Montañés, José Carlos Baena Muñoz, Miguel Velázquez, Ana Magdalena Sánchez, Rosa María Alegret i Jordà, Marta Laguna Egea, Juan Carlos |
Keywords: | Fructosa Glucosa Obesitat Efectes secundaris dels medicaments Rates Fructose Glucose Obesity Drug side effects Rats |
Issue Date: | 11-Oct-2018 |
Publisher: | Wiley-VCH |
Abstract: | Scope: The effect of chronic supplementation with simple-sugar solutions on leptin signaling in liver, hypothalamus, and visceral white adipose tissue (vWAT) is studied, which is designed to mimic the temporal pattern of consumption by humans. Methods and results: Solutions of fructose or glucose are isocalorically supplemented (7 months) in female Sprague-Dawley rats consuming ad libitum rodent chow. After sacrifice, plasma and tissue samples (liver, hypothalamus, and vWAT) are collected. Zoometric parameters, plasma analytes, and the tissue expression and activity of markers of leptin signaling are determined by biochemical and molecular biological methods. The two sugars cause different types of adiposopathy. Both sugars induce increases in plasma nonesterified fatty acids, and leptin resistance in the liver and the hypothalamus. Only fructose-supplemented rats show hyperleptinemia, and increased body weight due to a hypertrophy of vWAT, with no signs of leptin-mediated lipolysis. Glucose-supplemented rats show no significant changes in these parameters but present elevated plasma adiponectin concentrations, lipolysis, and inflammatory markers in vWAT, indicating a shift to a nonexpandable adipose tissue phenotype. Conclusion: Chronic consumption of fructose places a greater burden on metabolic homeostasis than equivalent consumption of glucose, inducing hyperleptinemia, generalized leptin resistance, and increased body weight due to expanded, hypertrophic vWAT. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.201800777 |
It is part of: | Molecular Nutrition & Food Research, 2018, vol. 62, num. 22, p. e1800777- |
URI: | http://hdl.handle.net/2445/167709 |
Related resource: | https://doi.org/10.1002/mnfr.201800777 |
ISSN: | 1613-4125 |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
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